Dental Mesenchymal Stem Cell:  Its role in tooth development, types, surface antigens and differentiation potential

Feter, Yohanna; Afiana, Nadhia Sari; Chandra, Jessica Nathalia; Abdullah, Kharima; Shafira, Jasmine; Sandra, Ferry

doi:10.21705/mcbs.v1i2.15

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…Stem cells from human exfoliated deciduous teeth (SHED) were first obtained by Miura et al in 2003. SHED expresses cell surface markers STRO-1, CD10, CD29, CD 31, CD44, CD73, CD90, CD105, CD146, CD13, CD166, Nestin, DCX, -tubulin, NeuN, GFAP, S-100, A2B5, CNPaseNanog, Oct3/4 and SSEAs (-3, -4) and does not express CD14, CD15, CD19, CD34, CD45, and CD43 [41,[56][57][58][59].…”

Section: Stem Cells From Human Exfoliated Deciduous Teeth (Shed)mentioning

confidence: 99%

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

et al. 2022

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Maintaining dental pulp vitality and preventing tooth loss are two challenges in endodontic treatment. A tooth lacking a viable pulp loses its defense mechanism and regenerative ability, making it more vulnerable to severe damage and eventually necessitating extraction. The tissue engineering approach has drawn attention as an alternative therapy as it can regenerate dentin-pulp complex structures and functions. Stem cells or progenitor cells, extracellular matrix, and signaling molecules are triad components of this approach. Stem cells from human exfoliated deciduous teeth (SHED) are a promising, noninvasive source of stem cells for tissue regeneration. Not only can SHEDs regenerate dentin-pulp tissues (comprised of fibroblasts, odontoblasts, endothelial cells, and nerve cells), but SHEDs also possess immunomodulatory and immunosuppressive properties. The collagen matrix is a material of choice to provide structural and microenvironmental support for SHED-to-dentin pulp tissue differentiation. Growth factors regulate cell proliferation, migration, and differentiation into specific phenotypes via signal-transduction pathways. This review provides current concepts and applications of the tissue engineering approach, especially SHEDs, in endodontic treatment.

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Section: Stem Cells From Human Exfoliated Deciduous Teeth (Shed)mentioning

confidence: 99%

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

et al. 2022

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“…7 MSCs can be found in organs and tissues, such as umbilical cord, umbilical cord blood, adult connective tissue, placenta, amniotic membranes, dental tissue, and bone marrow. 8,9 MSCs are expected to reduce lung damage, accelerate the recovery of damaged cells and improve patient survival.…”

Section: Introductionmentioning

confidence: 99%

Allogeneic Mesenchymal Stem Cells and Its Conditioned Medium as a Potential Adjuvant Therapy for COVID-19

Widowati

Faried

Kusuma³

et al. 2023

Mol Cell Biomed Sci

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Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This benefit occurs via a mechanism that promotes viral clearance by phagocytes and macrophages. This action occurs through the innate (increase in IL-10 production and decrease in TNF-α and IL-12 production) and the adaptive immune system (decrease in IL-17 production, promote regulatory T cell proliferation and inhibit effectors T cell proliferation). MSCs are expected to act as an anti-inflammatory in the hyper-inflammatory state of COVID-19. MSCs enhance immune cell replacement that have been overwhelmed or have been lost due to cytokine storm. Although vaccines are the answer to this pandemic, MSCs can improve COVID-19 patients, especially in patients with chronic illnesses. The focus on keeping death-rates low is a great opportunity for MSCs-based therapy for severe or critically ill patients. MSCs and conditioned medium have the potential to serve as adjunctive therapy in preventing the body's overactive defense response or the so-called cytokine storm caused by COVID-19.Keywords: adjuvant therapy, COVID-19, mesenchymal stem cells, secretome

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“…37 UC-MSCs are used more often than dental pulp stem cells (DPSCs), though dental pulp has been considered as an attractive source of MSCs due to its high cell content and relatively low invasive cell isolation procedure. 17,33,[38][39][40] DPSCs are similar to ASCs in their immunomodulatory properties. 33 There are 3 types of stem cell transplantation, i.e.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Mesenchymal Stem Cells in Burn Therapy: Systematic Review

Dini¹,

Nugraha²,

Revina³

et al. 2022

Mol Cell Biomed Sci

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The experimental research on the use of mesenchymal stem cells (MSCs) for burn therapy has been published several times. However, current clinical procedure remains a challenging discussion. This systematic review assesses the safety and efficacy of administering mesenchymal stem cells (MSCs) to burns and determines the most effective source of MSCs for burn therapy. We reviewed several studies through PubMed, Google Scholar, Science Direct, and DOAJ online databases. PRISMA-P 2020 method was used based on inclusion and exclusion criteria that were re-selected through Joanna Briggs Institute (JBI) Critical Appraisal Tools. Results from 13 articles showed that MSCs are safe for burn therapy with minimal side effects/complications and have the potential to repair tissue and accelerate burn healing through several mechanisms. The treatment of MSCs in burns is influenced by donor characteristics and related to the severity and area of the burn. It can be concluded that the administration of MSCs is safe and effective in burn therapy. Keywords: burns, mesenchymal stem cells, therapeutic safety, therapeutic efficacy, wound healing

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Dental Mesenchymal Stem Cell: Its role in tooth development, types, surface antigens and differentiation potential

Cited by 8 publications

References 54 publications

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

Allogeneic Mesenchymal Stem Cells and Its Conditioned Medium as a Potential Adjuvant Therapy for COVID-19

Safety and Efficacy of Mesenchymal Stem Cells in Burn Therapy: Systematic Review

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