Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53-mediated pathway

Yang, Haibo; Song, Wei; Cheng, Mei‐Die; Haifang, Fan; Gu, Xu; Qiao, Ying; Lü, Xin; Yu, Rui‐He; Chen, Lan‐Ying

doi:10.3892/mmr.2014.3004

Cited by 18 publications

(17 citation statements)

References 28 publications

(29 reference statements)

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“…Thus, some studies focused on the role of p53 in mediating cell apoptosis induced by chemotherapeutic agents. 30,32,33 In this study, we found that the level of p53 was significantly increased due to treatment with alantolactone, which further suggested that p53 was a key gene in the apoptosis of BGC 823 and SGC-7901 cells.…”

Section: Discussionsupporting

confidence: 57%

Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

et al. 2019

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Background: Gastric cancer is a malignant tumor with high incidence rate and mortality rate. Purpose: In this study, we investigated the anti-cancer effect of alantolactone, a sesquiterpene lactone, on gastric cancer cell lines BGC-823 and SGC-7901. Methods: BGC-823 and SGC-7901 cells were treated with different concentrations of alantolactone, Hoechst 33258 staining, flow cytometry, wound healing assay, invasion assay, colony forming assay, quantative polymerase chain reaction, and western blot analysis were used to evaluate the anticancer activity of alantolactone to gastric cancer. Results: Alantolactone induced apoptosis of gastric cancer cells by regulating the expression of Bax, Bcl-2, and p53, which related to intrinsic apoptotic pathway, and suppressed colony formation, migration, and invasion by mediating the expression of matrix metalloproteinase (MMP)-2, MMP-7, and MMP-9. Cell signaling pathway analysis showed that alantolactone enhanced the phosphorylation of p38 and decreased the translocation of nucleus p65, suggesting that the apoptosis-promoting and migration-suppressing effect of alantolactone might at least partially rely on regulating p38 mitogen-activated protein kinase (p38MAPK) pathway and nuclear factor-κB (NF-κB) pathway. Conclusions: Alantolactone can be used as a potential therapeutic agent for treating gastric cancer.

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Section: Discussionsupporting

confidence: 57%

Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

et al. 2019

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“…Yang et al. pointed out that on the one hand, DCA can inhibit the proliferation of gastric carcinoma cells by arresting the cell cycle in the G0/G1 phase, and on the other hand, it can induce apoptosis of gastric carcinoma cells via a p53-mediated pathway ( 52 ). Jang et al.…”

Section: Bile Acids In Cancer Cell Proliferation and Deathmentioning

confidence: 99%

Research Progress of Bile Acids in Cancer

Min

et al. 2022

Front. Oncol.

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Bile acids (BAs) were originally known as detergents to facilitate the digestion and absorption of lipids. And our current knowledge of BAs has been extended to potential carcinogenic or cancer suppressor factors due to constant research. In fact, BAs were regarded as a tumor promoters as early as the 1940s. Differential bile acid signals emitted by various bile acid profiles can produce distinct pathophysiological traits, thereby participating in the occurrence and development of tumors. Nevertheless, in recent years, more and more studies have noticed the value of BAs as therapeutic targets. And several studies have applied BAs as a therapeutic agent for various diseases including cancer. Based on the above evidence, we acknowledge that the role of BAs in cancer has yet to be exploited, although considerable efforts have been made to probe the functions of BAs. In this review, we describe the characteristics of BAs as a double-edged sword in cancer, hoping to provide references for future cancer treatments.

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“…In the recent years, potential anticancer properties of NaDCA have gained increasing attention because of at least two reasons: (i) NaDCA has been reported to inhibit proliferation and to induce apoptosis in cells obtained from human colon cancer [48,49] and gastric carcinoma [50]; (ii) coupling with bile acid (such as deoxycholic acid) moieties has been suggested to be a promising strategy for liver-targeted drug delivery due to the presence of bile acid receptors on hepatocytes [51]. Deoxycholic acid modified conjugates have been developed and proposed as suitable novel carriers for anticancer drugs including epirubicin and paclitaxel [52,53].…”

Section: Biological Evaluationmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH DEOXYCHOLATE LIGAND

Culiţă¹

2021

FARMACIA

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Three new complexes of Ni(II), Cu(II) and Zn(II) with deoxycholate anion, of the type M(DCA) 2 • nH 2 O (M = Cu(II) n = 4, M = Ni(II) n = 3 and M = Zn(II) n = 2) have been synthesized and characterized on the basis of elemental analysis, FTIR and UV-Vis spectroscopy, thermal analysis, molar conductivity and magnetic measurements. The cytotoxicity of the synthesized complexes was tested against HT29 human colorectal cancer cells. Applied at a concentration range of 10 -200 µg/mL, sodium deoxycholate and its metal complexes have been found to decrease viability and growth of cultured HT29 cells in a time-and concentration-dependent manner in short-term and long-term experiments. The ability of the complexes to induce pathological changes, genotoxicity and apoptosis in the treated cells has also been proved. In addition, the complexes demonstrated a cytotoxic effect in HT29-OxPt (resistant to oxaliplatin) cells, allowing to conclude that they are more pronounced cytotoxic agents as compared to the sodium deoxycholate alone. RezumatTrei noi complecși ai Ni(II), Cu(II) și Zn(II) cu anionul deoxicolat, de tipul M(DCA) 2 • nH 2 O (M = Cu(II) n = 4, M = Ni(II) n = 3 și M = Zn(II) n = 2), au fost sintetizați și caracterizați pe baza analizei elementale, a spectroscopiei FTIR și UV-Vis, analizei termice, conductivității molare și a măsurătorilor magnetice. Citotoxicitatea complecșilor sintetizați a fost testată pe celule canceroase colorectale umane HT29. La concentrații de 10 -200 µg/mL, s-a observat că deoxicolatul de sodiu și complecșii săi metalici scad viabilitatea și dezvoltarea celulelor colorectale umane HT29 cultivate, într-o manieră dependentă de timp și concentrație, în experimente pe termen scurt și pe termen lung. Capacitatea complecșilor de a induce modificări patologice, genotoxicitate și apoptoză în celulele tratate a fost de asemenea dovedită. În plus, complecșii au demonstrat un efect citotoxic asupra celulelor HT29-OxPt (rezistente la oxaliplatină), permițându-ne să concluzionăm că sunt agenți citotoxici mai puternici comparativ cu deoxicolatul de sodiu.

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Deoxycholic acid inhibits the growth of BGC-823 gastric carcinoma cells via a p53-mediated pathway

Cited by 18 publications

References 28 publications

Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-κB pathways

Research Progress of Bile Acids in Cancer

SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH DEOXYCHOLATE LIGAND

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