2013
DOI: 10.1155/2013/926584
|View full text |Cite
|
Sign up to set email alerts
|

Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates

Abstract: We previously reported the synthesis of three DOX conjugates that represented different targeting vehicles and showed them to have antitumor activity both in vitro and in vivo. However, the relationships between the pharmacokinetics of these DOX conjugates and their chemical structures were not characterized. In the current study, free DOX derived from each of the conjugates was found at low levels in the rat circulatory system, with conjugated DOX being the major form. The two polyethylene glycol (PEG) conjug… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2015
2015
2020
2020

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 26 publications
0
3
0
Order By: Relevance
“…The Luna Omega C18 column exhibited better separation, an excellent peak shape, and good sensitivity for the analytes using a gradient elution of 0.1% formic acid in 95% methanol and 0.1% formic acid in 0.1% formic acid in 5% methanol compared with the Halo C18 and Acquity BEH C18 columns. Using methanol instead of acetonitrile [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] as the strong eluent of the mobile phase resulted in increased ionization efficiency and linearity range for the five analytes. Daunorubicin, an analog of doxorubicin, was selected as and the internal standard (IS).…”
Section: Lc-ms/ms Analysismentioning
confidence: 99%
See 1 more Smart Citation
“…The Luna Omega C18 column exhibited better separation, an excellent peak shape, and good sensitivity for the analytes using a gradient elution of 0.1% formic acid in 95% methanol and 0.1% formic acid in 0.1% formic acid in 5% methanol compared with the Halo C18 and Acquity BEH C18 columns. Using methanol instead of acetonitrile [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] as the strong eluent of the mobile phase resulted in increased ionization efficiency and linearity range for the five analytes. Daunorubicin, an analog of doxorubicin, was selected as and the internal standard (IS).…”
Section: Lc-ms/ms Analysismentioning
confidence: 99%
“…Doxorubicinol, a major alcohol metabolite of doxorubicin formed by carbonyl reductases 1 and 3, is implicated in off-target cardiotoxicity of doxorubicin-treated patients [3,[7][8][9][10]. High-performance liquid chromatography (HPLC) with fluorescence [11][12][13][14][15][16][17][18][19] or ultraviolet (UV) [20,21] detection, LC with mass spectrometry (LC-MS) [22,23] or tandem mass spectrometry (LC-MS/MS) [24][25][26][27][28][29][30][31][32][33][34][35][36], and capillary electrophoresis [37][38][39] methods have been used to analyze doxorubicin alone or with its metabolite doxorubicinol in various biological matrices, such as blood, serum, plasma, cells, and tissues. Protein precipitation with methanol, acetonitrile, or acetone [13][14][15]18,19,21,22,[25][26][27]31,…”
Section: Introductionmentioning
confidence: 99%
“…Adapted from [36]. similar effects with low molecular weight (18 kDa) FGF-2, the protection against doxorubicin-induced damage may be due to an increase in efflux drug transport [67]. It is unclear, however, whether endogenous FGF-16 offers significant protection from doxorubicin-induced damage, but it is likely that synthesis of FGF-16 would be negatively affected.…”
Section: Exogenous Fgf-16 Is Cardioprotectivementioning
confidence: 99%