Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum

Leret, M.L.; Millán, Jose Antonio San; Fabre, Elodie; Gredilla, Ricardo; Barja, Gustavo

doi:10.1016/s0300-483x(01)00541-8

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…Despite an absence of statistic significance, all brain structures studied presented a tendency to reduced GR activity at 6 or 24 h after MPTP treatment, which is in accordance to the importance of GR in clearing GSSG (Leret et al, 2002). GPx activity tended to be lowered in the ST, HC and PFC, but not in the OB.…”

Section: Discussionsupporting

confidence: 67%

Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb

et al. 2007

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Section: Discussionsupporting

confidence: 67%

Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb

et al. 2007

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“…MPTP-administered rats displayed typical behavioral characteristics of PD in the vertical pole and catalepsy tests [33]. These findings were in agreement with results from previous studies which demonstrated the impairment of motor activity in MPTP-induced Parkinsonism models [50][51][52][53][54]. On the other hand, DHA administration re- www.fhc.viamedica.pl duced these symptoms in the MPTP-induced + DHA--treated group [33].…”

Section: Discussionsupporting

confidence: 90%

Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease

Hacioglu

Seval-Celik

Tanrıöver

et al. 2012

Folia Histochem Cytobiol.

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Docosahexaenoic acid (DHA), a major polyunsaturated fatty acid (PUFA) in the phospholipid fraction of the brain, is essential for normal cellular function. Neurodegenerative disorders such as Parkinson's disease (PD) often exhibit significant declines in PUFAs. The aim of this study was to observe the effects of DHA supplementation in an experimental rat model of PD created with '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine' (MPTP). Adult male Wistar rats were divided into four groups: (1) Control; (2) DHA-treated; (3) MPTP-induced; and (4) MPTP-induced + DHA-treated. Motor activity was investigated using the 'vertical pole' and 'vertical wire' tests. The dopaminergic lesion was determined by immunohistochemical analysis for tyrosine hydroxylase (TH)-immunopositive cells in substantia nigra (SN). Immunoreactivities of Bcl-2, Akt and phosphorylated-Akt (p-Akt) in SN were evaluated by immunohistochemistry. MPTP-induced animals exhibited decreased locomotor activity, motor coordination and loss of equilibrium. Diminished Parkinsonism symptoms and decreased dopaminergic neuron death were detected in the MPTP-induced + DHA-treated group compared to the MPTP-induced group. Moderate decreases in Akt staining were found in the MPTP-induced and MPTP-induced + DHA-treated groups compared to controls. p-Akt immunoreactivity decreased dramatically in the MPTP-induced group compared to the control; however, it was increased in the MPTP-induced + DHA--treated group compared to the MPTP-induced group. The staining intensity for Bcl-2 decreased prominently in the MPTP-induced group compared to the control, while it was stronger in the MPTP-induced + DHA-treated group compared to the MPTP-induced group. In conclusion, DHA significantly protects dopaminergic neurons against cell death in an experimental PD model. Akt/p-Akt and Bcl-2 pathways are related to this protective effect

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“…We measured ROS generation and total GSH level after treatment of 6-OHDA with or without DJS as a measure of oxidative stress. It is known that ROS can damage cell structures (Prokai et al, 2005) and GSH plays an important role in neuroprotection against oxidative stress in damaged DA neurons (Leret et al, 2002). Pre-treatment with DJS at 0.1, 0.5, and 1 g/mL significantly reduced ROS production by 6-OHDA ( Fig.…”

Section: Resultsmentioning

confidence: 86%

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

Hwang

Kim

Kwon

et al. 2011

Journal of Ethnopharmacology

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Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum

Cited by 22 publications

References 31 publications

Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb

Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb

Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease

Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity

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