Locus of Control (LOC) refers to an individual's personal belief that the events which occur in his or her life are either as a result of personal control and effort, or outside forces such as fate and luck. Self esteem refers to the extent to which a person values, approves or appreciates himself or herself. Self esteem has a prominent effect on one's mental health as well as personal balance. Adolescent is a stage in individual growth and development which has been notorious throughout the centuries as one of great emotional upset with wide fluctuations in behavior.The Locus of control scale, the Self esteem scale and the Beck's depression inventory-2 were used to assess locus of control, self esteem and depression among 720 school going adolescents from two Nigerian rural communities. Result revealed various levels of locus of control, self esteem and depression among the respondents.