Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications

Shao, Mingjing; Lin, Xiaodong; Jiang, Deguo; Tian, Hongjun; Xu, Yong; Wang, Lina; Feng, Jia‐Xun; Zhou, Chunhua; Song, Xueqing; Zhuo, Chuanjun

doi:10.1016/j.psychres.2020.112802

Cited by 85 publications

(68 citation statements)

References 61 publications

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“…In addition, because depressive disorders are characterized by chronic stress, levels of circulating cortisol are increased in the long term. In this setting, immune cells become insensitive to the regulatory effects of cortisol and contribute to the chronic inflammation seen in depressed patients ( 34 ). Cortisol also increases arterial contractile sensitivity to NE and suppresses the production of prostacyclin and nitric oxide in endothelial cells, thereby resulting in higher vascular resistance ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

Antidepressant Drugs Effects on Blood Pressure

Calvi

Fischetti

Verzicco

et al. 2021

Front. Cardiovasc. Med.

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Individuals suffering from depressive disorders display a greater incidence of hypertension compared with the general population, despite reports of the association between depression and hypotension. This phenomenon may depend, at least in part, on the use of antidepressant drugs, which may influence blood pressure through different effects on adrenergic and serotoninergic pathways, as well as on histaminergic, dopaminergic, and cholinergic systems. This review summarizes extant literature on the effect of antidepressant drugs on blood pressure. Selective serotonin reuptake inhibitors are characterized by limited effects on autonomic system activity and a lower impact on blood pressure. Thus, they represent the safest class—particularly among elderly and cardiovascular patients. Serotonin–norepinephrine reuptake inhibitors, particularly venlafaxine, carry a greater risk of hypertension, possibly related to greater effects on the sympathetic nervous system. The norepinephrine reuptake inhibitor reboxetine is considered a safe option because of its neutral effects on blood pressure in long-term studies, even if both hypotensive and hypertensive effects are reported. The dopamine–norepinephrine reuptake inhibitor bupropion can lead to blood pressure increases, usually at high doses, but may also cause orthostatic hypotension, especially in patients with cardiovascular diseases. The norepinephrine–serotonin modulators, mirtazapine and mianserin, have minimal effects on blood pressure but may rarely lead to orthostatic hypotension and falls. These adverse effects are also observed with the serotonin-reuptake modulators, nefazodone and trazodone, but seldomly with vortioxetine and vilazodone. Agomelatine, the only melatonergic antidepressant drug, may also have limited effects on blood pressure. Tricyclic antidepressants have been associated with increases in blood pressure, as well as orthostatic hypotension, particularly imipramine. Oral monoamine–oxidase inhibitors, less frequently skin patch formulations, have been associated with orthostatic hypotension or, conversely, with hypertensive crisis due to ingestion of tyramine-containing food (i.e., cheese reaction). Lastly, a hypertensive crisis may complicate antidepressant treatment as a part of the serotonin syndrome, also including neuromuscular, cognitive, and autonomic dysfunctions. Clinicians treating depressive patients should carefully consider their blood pressure status and cardiovascular comorbidities because of the effects of antidepressant drugs on blood pressure profiles and potential interactions with antihypertensive treatments.

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Section: Methodsmentioning

confidence: 99%

Antidepressant Drugs Effects on Blood Pressure

Calvi

Fischetti

Verzicco

et al. 2021

Front. Cardiovasc. Med.

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“…If viewed through the lens of these facts, the presence of psychopathology in association with higher levels of comorbidity in older individuals can be considered as an expression of lower resilience, maladaptive coping, and unsuccessful aging. In this regard, in a meta-analysis where authors explored associations between high resilience and mental health, high resilience was found to be positively associated with good mental health, positive affect, and life satisfaction, and negatively associated with depression, anxiety, and pessimistic affect [37].…”

Section: Psychological Social and Biological Aspects Of Resilience In Older Age And Their Associations Within Successful Aging (The Biopsmentioning

confidence: 99%

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

Majnarić

Bosnić

Guljaš

et al. 2021

IJMS

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The term resilience, which has been present in science for almost half a century, stands for the capacity of some system needed to overcome an amount of disturbance from the environment in order to avoid a change to another stable state. In medicine, the concept of resilience means the ability to deal with daily stress and disturbance to our homeostasis with the intention of protecting it from disturbance. With aging, the organism becomes more sensitive to environmental impacts and more susceptible to changes. Mental disturbances and a decline in psychological resilience in older people are potentiated with many social and environmental factors along with a subjective perception of decreasing health. Distinct from findings in younger age groups, mental and physical medical conditions in older people are closely associated with each other, sharing common mechanisms and potentiating each other’s development. Increased inflammation and oxidative stress have been recognized as the main driving mechanisms in the development of aging diseases. This paper aims to reveal, through a translational approach, physiological and molecular mechanisms of emotional distress and low psychological resilience in older individuals as driving mechanisms for the accelerated development of chronic aging diseases, and to systematize the available information sources on strategies for mitigation of low resilience in order to prevent chronic diseases.

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Section: профилактика у взрослых среднего возрастаunclassified

“…Существует тесная связь депрессии с ССЗ [33]. Недавно проведенные исследования показали, что депрессия и ССЗ могут проявляться как два различных клинических состояния, но могут также быть связаны общими механизмами [33]. Воспаление с участием иммунной системы является распространенным механизмом депрессии и ССЗ, при этом специфические воспалительные цитокины служат потенциальными мишенями для профилактики и лечения, что может иметь значимые клинические последствия для профилактики и раннего вмешательства при депрессии и ССЗ [33].…”

Section: профилактика у взрослых среднего возрастаunclassified

Lifetime prevention of cardiovascular disease. Part III: young, middle, elderly and senile age

Копылова¹,

Ершова²,

Мешков³

et al. 2021

Cardiovasc Ther Prev

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Intensive investigation of cardiovascular disease (CVD) risk factors (RFs), both traditional (smoking, dyslipidemia, diabetes, etc.) and non-traditional, which are a component of the so-called exposome, as well as their non-drug and drug correction provide wide prospects for effective cardiovascular prevention. Prevention becomes the dominant trend in cardiology and in medicine in general. The aim of the article was to describe cardiovascular prevention in young, middle, elderly and senile age. Due to the multifaceted nature of cardiovascular RFs, an integrated biopsychosocial approach, individual and population-based prevention, cumulative risk assessment of all CVDs, intersectoral collaboration and the involvement of decision-makers, are key to the success and effectiveness of prevention measures. It is important to note that, on the one hand, preventive measures should be started as early as possible due to cumulative effect of RFs, on the other hand, most of the preventive interventions for CVD are extremely relevant at all life stages.

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Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications

Cited by 85 publications

References 61 publications

Antidepressant Drugs Effects on Blood Pressure

Antidepressant Drugs Effects on Blood Pressure

Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions

Lifetime prevention of cardiovascular disease. Part III: young, middle, elderly and senile age

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