Depression and Employment Status in Primary and Tertiary Care Settings

Rizvi, Sakina J.; Cyriac, Anna; Grima, Etienne A.; Tan, Mary; Lin, Peter; Gallaugher, Laura Ashley; McIntyre, Roger S.; Kennedy, Sidney H.

doi:10.1177/070674371506000105

Cited by 71 publications

(58 citation statements)

References 41 publications

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“…41 In Canada, workers with MDD, compared to those without depression, were twice as likely to leave work during a 10-year follow-up. 42 Increased severity of illness, 43 concurrent medical conditions, 44 and comorbid anxiety disorders 45 result in a higher degree of work disability and greater absenteeism in people with MDD. In addition to overall severity, individual symptoms of MDD can differentially affect workplace performance.…”

Section: What Is the Occupational Impact Of Mdd?mentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

et al. 2016

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Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals. Methods: Using the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. This section is the first of six guidelines articles.Results: In Canada, the annual and lifetime prevalence of MDD was 4.7% and 11.3%, respectively. MDD represents the second leading cause of global disability, with high occupational and economic impact mainly attributable to indirect costs. DSM-5 criteria for depressive disorders remain relatively unchanged, but other clinical dimensions (sleep, cognition, physical symptoms) may have implications for depression management. e-Mental health is increasingly used to support clinical and selfmanagement of MDD. In the 2-phase (acute and maintenance) treatment model, specific goals address symptom remission, functional recovery, improved quality of life, and prevention of recurrence. Conclusions:The burden attributed to MDD remains high, whether from individual distress, functional and relationship impairment, reduced quality of life, or societal economic cost. Applying core principles of care, including comprehensive assessment, therapeutic alliance, support of self-management, evidence-informed treatment, and measurement-based care, will optimize clinical, quality of life, and functional outcomes in MDD.

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Section: What Is the Occupational Impact Of Mdd?mentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

et al. 2016

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“…Major depressive disorder (MDD), or unipolar depression (henceforth referred to as 'depression'), has a significant negative impact on life functioning and on work-related outcomes such as employment status [1][2][3][4][5] and work productivity, including absenteeism and presenteeism [2,6]. In fact, MDD has one of the highest levels of negative impact on work outcomes, higher than rheumatoid arthritis [7,8], ischemic heart disease [8], and other mood disorders including anxiety [9].…”

Section: Introductionmentioning

confidence: 98%

Cognitive dysfunction and work productivity in major depressive disorder

Clark

DiBenedetti

Pérez

2016

Expert Review of Pharmacoeconomics & Outcomes Research

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Given the prevalence of cognitive dysfunction, and the humanistic and economic impact of occupational impairments in individuals with MDD, the relationship between cognitive dysfunction in MDD and work-related outcomes requires characterization. A selective review of the literature was conducted to better understand and further highlight this relationship. Expert commentary: Although current evidence is limited, MDD-related cognitive dysfunction may have a direct negative impact on work productivity. Presenteeism is the key outcome impacted by cognitive deficits in MDD. Additional well-designed prospective observational research may clarify how cognitive dysfunction influences the MDD-work productivity relationship. Use of reliable, valid, and sensitive measures of cognitive functioning and work productivity in MDD is warranted.

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“…When people are socially excluded or have a greater sensitivity to rejection, four fundamental needs are proposed to be affected: belonging, self-esteem, control and meaningful existence which are required for human survival and effective social functioning (Williams, Cheung, & Choi, 2000). The impairment of social functioning is proposed to be reliable indicator of depression (Cheng & Furnham, 2003;Hirschfeld et al, 2000) and these dysfunctions in social interactions were reported to persist even after three years of recovery from depressive symptoms (Rhebergen et al, 2010) and correlated with unemployment, disability and decreased work performance (Rizvi et al, 2015). Further, depressed individuals possess specific traits that increase the likelihood they will experience interpersonal stress and have subsequent depressive episodes (Hammen, 2005).…”

Section: Introductionmentioning

confidence: 99%

Increased neural response to social rejection in major depression

et al. 2017

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Background Being a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD. Methods To this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups. Results We showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self‐esteem scores across all participants. Conclusions These preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.

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Depression and Employment Status in Primary and Tertiary Care Settings

Abstract: Unemployment and disability rates in MDD are high. The presence of anhedonia and medical comorbidity significantly influenced work status, emphasizing the need for treatment strategies to alleviate the additional symptom burden in this subpopulation.

Cited by 71 publications

References 41 publications

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

Cognitive dysfunction and work productivity in major depressive disorder

Increased neural response to social rejection in major depression

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