Depression and schizophrenia in epilepsy: social and biological risk factors

Schmitz, Erika; Robertson, Mary M.; Trimble, Michael

doi:10.1016/s0920-1211(98)00129-6

Cited by 81 publications

(44 citation statements)

References 11 publications

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“…This result is in accordance with earlier studies [5,6,15,21,22,25]. While in some of them, left-sided pathology was the most frequent finding, others found bilateral alterations [9,10,20,23]. Unilateral pathologies predominated in our patients, but left-sided locations did not outweigh right-sided ones.…”

Section: Discussionsupporting

confidence: 93%

EEG: a helpful tool in the prediction of psychosis

Gschwandtner

Pflueger

Semenin

et al. 2009

Eur Arch Psychiatry Clin Neurosci

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j Abstract Objective EEG investigation in patients with an at risk mental state (ARMS) for psychosis and patients with a first episode of psychosis (FE) in comparison to healthy controls (HC) in a clinical follow up study of Early Detection of Psychosis. Method Seventy-three patients (42 ARMS, 31 FE) and 35 HC were investigated. ARMS patients were followed up in order to monitor transition to psychosis. Psychopathology was assessed with respect to positive and negative symptoms. At study baseline EEG was recorded using the 10/20 system. Two blinded neurologists analyzed the EEGs visually for presence of generalized or focal slowing and epileptiform discharges. EEG data were controlled for medication and substance abuse. For statistical analyses we used v 2 -tests, logistic regression, ANOVA, and receiver operating characteristics. Results Patients showed significantly more pathological EEG abnormalities than HC (P < 0.05), located more frequently in temporal or fronto-temporal regions (P < 0.01) of the brain, with twice as many pathologies in ARMS than in FE patients. The specificity of the prediction of psychosis could be increased from 59 to 73% by considering EEG pathology in addition to psychopathology alone. In contrast, sensitivity of prediction remained unchanged. Conclusions These results show that EEG investigation in patients at risk for psychosis can add to the identification of those patients who will not develop psychosis later on.

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Section: Discussionsupporting

confidence: 93%

EEG: a helpful tool in the prediction of psychosis

Gschwandtner

Pflueger

Semenin

et al. 2009

Eur Arch Psychiatry Clin Neurosci

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“…[45]. Typically patients with comorbid epilepsy and schizophrenia have an earlier onset of seizures, with seizures typically and often by years preceding the onset of psychotic symptoms; more severe seizures; vegetative seizure symptoms; frequently temporal lobe discharges; and a likelihood of Schneiderian first rank symptoms, fitting a picture of so-called nuclear schizophrenia [34,35,46]. With the exception of the presence of Schneiderian first rank symptoms in all three, the presence of olfactory hallucinations in one, and an early age of onset followed by psychosis in another, our patients did not strongly fit the epilepsy/schizophrenia profile.…”

Section: Discussionmentioning

confidence: 99%

Tourette syndrome and comorbid early-onset schizophrenia

Kerbeshian¹,

Peng²,

Burd³

2009

Journal of Psychosomatic Research

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“…Forced normalization can be observed in both generalized and partial epilepsies as a rare complication. It is relatively frequently observed in adults with persistent absence seizures (Wolf, 1991;Kanner, 2000Kanner, , 2001Schmitz et al, 1999;Marsh & Rao, 2002). The term forced normalization is often considered in connection with EEG but Tellenbach in 1965 introduced in this connection the term alternative psychosis implicating that stopping seizures does not mean vanishing or inactivity of the pathological state (Wolf & Trimble, 1985;Krishnamoorthy et al, 2002).…”

Section: Relationship Between Epilepsy and Mental Illness: Implicatiomentioning

confidence: 99%

Dissociation, Epileptiform Discharges and Chaos in the Brain: Toward a Neuroscientific Theory of Dissociation

Bob

2012

Act Nerv Super

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Dissociated states represent pathological conditions when psychological trauma may emerge in a variety of forms such as psychic dissociative symptoms or, on the contrary, as paroxysms or other somatoform symptoms. There is evidence that epileptic activity plays an important role in the generation of dissociative states and it is able to generate various psychopathological processes as well as a wide spectrum of somatic symptoms or seizures. For the explanation of these connections between dissociative states and epileptic discharges the author proposes a neuroscientific model of dissociation based on the theory of competitive neural assemblies which can lead to chaotic self-organization in brain neural networks. This model is suggested as an integrative view interconnecting the various psychopathological and somatoform manifestations of dissociative states and suggests further possibilities for future research regarding common pathogenic mechanisms among epilepsy and mental disorders.

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Depression and schizophrenia in epilepsy: social and biological risk factors

Cited by 81 publications

References 11 publications

EEG: a helpful tool in the prediction of psychosis

EEG: a helpful tool in the prediction of psychosis

Tourette syndrome and comorbid early-onset schizophrenia

Dissociation, Epileptiform Discharges and Chaos in the Brain: Toward a Neuroscientific Theory of Dissociation

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