Depression in Patients with Cardiovascular Disease

Mastrogiannis, Dimos; Giamouzis, Grigorios; Dardiotis, Efthimios; Karayannis, George; Chroub-Papavaiou, Artemis; Kremeti, Dimitra; Spiliopoulos, Kyriakos; Georgoulias, Panagiotis; Koutsias, Stelios; Bonotis, Konstantinos; Mantzorou, Marianna; Skoularigis, John; Hadjigeorgiou, Georgios M.; Butler, Javed; Triposkiadis, Filippos

doi:10.1155/2012/794762

Cited by 17 publications

(13 citation statements)

References 91 publications

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“…2, we used ECG to examine the electrical activity of the heart of aged adult mice. Student's t test comparisons in aged mice revealed no significant difference between genotypes with regard to HR [ t (21) = 0.737; P . 0.05] or in R–R intervals [ t (21) = 0.618; P .…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, aged HCM mice exhibited significantly lower HRV [ t (21) = 5.984; P < 0.05], lower coefficient of variation (CV) [ t (21) = 5.555; P < 0.0001], and lower RMSSD [ t (21) = 4.483; P < 0.0005] vs. controls, which indicates compromised parasympathetic tone in the HCM females. Similarly, aged HCM mice exhibited lower levels of total power [ t (21) = 3.315; P < 0.005], reduced LF component of HRV [ t (21) = 3.103; P < 0.01], and reduced HF component of HRV [ t (21) = 2.751; P < 0.05] as compared to aged‐matched controls. Taken together, these results serve as evidence of SNS excitation and reduced efferent vagal activity in aged adult mice with HCM.…”

Section: Resultsmentioning

confidence: 99%

“…There are many reports that individuals with HCM are at a higher risk for anxiety and depression, compared with the general population (17)(18)(19)(20). This difference has also been demonstrated in individuals with heart failure and other forms of cardiovascular disease (21,22). The comorbid expression of a heart condition and mood disorder significantly worsen quality of life (23).…”

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confidence: 94%

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Pathogenesis of depression‐ and anxiety‐like behavior in an animal model of hypertrophic cardiomyopathy

et al. 2017

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Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence males. Our results showed that young and aged HCM mice displayed echocardiographic characteristics of the heart disease condition, yet only aged HCM females displayed anxiety- and depression-like behaviors. Electrocardiographic parameters of sympathetic nervous system activation were increased in aged HCM females controls and correlated with mood disorder-related symptoms. In addition, when compared with controls, aged HCM females exhibited adrenal gland hypertrophy, reduced volume in mood-related brain regions, and reduced hippocampal signaling proteins, such as brain-derived neurotrophic factor and its downstream targets controls. In conclusion, prolonged systemic HCM stress can lead to development of mood disorders, possibly through inducing structural and functional brain changes, and thus, mood disorders in patients with heart disease should not be considered solely a psychologic or situational condition.-Dossat, A. M., Sanchez-Gonzalez, M. A., Koutnik, A. P., Leitner, S., Ruiz, E. L., Griffin, B., Rosenberg, J. T., Grant, S. C., Fincham, F. D., Pinto, J. R. Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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confidence: 94%

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Pathogenesis of depression‐ and anxiety‐like behavior in an animal model of hypertrophic cardiomyopathy

et al. 2017

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“…Premature cardiovascular disease is the most common cause of morbidity and mortality in people with diabetes [30] and co-morbid depression appears to increase the risk of developing vascular conditions in this group [11], [15], [17]. However, depression is also common in people with established cardiovascular disease [31]. Rather than being a (in)direct causal factor, depression in diabetes may be secondary to having cardiovascular complications.…”

Section: Discussionmentioning

confidence: 99%

Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2013

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ObjectiveTo examine the association between depression and all-cause and cardiovascular mortality in people with diabetes by systematically reviewing the literature and carrying out a meta-analysis of relevant longitudinal studies.Research Design and MethodsPUBMED and PSYCINFO were searched for articles assessing mortality risk associated with depression in diabetes up until August 16, 2012. The pooled hazard ratios were calculated using random-effects models.ResultsSixteen studies met the inclusion criteria, which were pooled in an overall all-cause mortality estimate, and five in a cardiovascular mortality estimate. After adjustment for demographic variables and micro- and macrovascular complications, depression was associated with an increased risk of all-cause mortality (HR = 1.46, 95% CI = 1.29–1.66), and cardiovascular mortality (HR = 1.39, 95% CI = 1.11–1.73). Heterogeneity across studies was high for all-cause mortality and relatively low for cardiovascular mortality, with an I-squared of respectively 78.6% and 39.6%. Subgroup analyses showed that the association between depression and mortality not significantly change when excluding three articles presenting odds ratios, yet this decreased heterogeneity substantially (HR = 1.49, 95% CI = 1.39–1.61, I-squared = 15.1%). A comparison between type 1 and type 2 diabetes could not be undertaken, as only one study reported on type 1 diabetes specifically.ConclusionsDepression is associated with an almost 1.5-fold increased risk of mortality in people with diabetes. Research should focus on both cardiovascular and non-cardiovascular causes of death associated with depression, and determine the underlying behavioral and physiological mechanisms that may explain this association.

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“…Consultation should be provided by a multidisciplinary team, consisting of cardiologists, psychiatrists, and hospital or community nurses so as to carefully plan, execute, and evaluate medical intervention and implement lifestyle changes. D. Mastrogiannis et al [11] systematically review the existing knowledge regarding current definitions, prognostic implications, pathophysiological mechanisms, and current and future treatment options in patients with depression and HF. Evidence from the literature supports the possibility of a pathophysiological relationship between cognitive impairment, depression, and HF.…”

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confidence: 99%