Depressive effects of lipid peroxides mediated via a purine receptor

Hasegawa, Tohru

doi:10.1016/0006-2952(90)90441-m

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…53 There are, however, conflicting data suggesting that pro-oxidant conditions reduce the ionic gating of the NMDA receptor site, 54 and that lipid peroxides act pharmacologically as depressants. 55 Some of these apparent contradictions may be due to the key role of iron in ROS production. The presence of ionic iron is essential in the promotion of post-ischemic lipid peroxidation, 56 and iron liberation from sequestration sites within proteins is closely related to tissue pH.…”

Section: The Relation Between Excitatory and Oxidant Eventsmentioning

confidence: 99%

The relationship between excitotoxicity and oxidative stress in the central nervous system

Bondy

LeBel

1993

Free Radical Biology and Medicine

153

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Abstract-Excitotoxicity and oxidative stress are two phenomena that have been repeatedly described as being implicated in a wide range of disorders of the nervous system. Such disorders include several common idiopathic neurological diseases, traumatic brain injury, and the consequences of exposure to certain neurotoxic agents. While there is evidence that metabolic derangements can lead to these adverse processes, and that these processes may synergize in their damaging effects, the degree of interdependence, and the causal relation between them is not clear. The intent of this review is to delineate potential mechanisms which may unit hyperexcitation to the excessive generation of reactive oxygen species. The degree of linkage between these events appears rather strong. It is likely that excitoxicity frequently leads to a pro-oxidant condition but that high rates of generation of reactive oxygen species are not invariably accompanied by a hyperexcited neuronal state Both excitoxic and 'oxidotoxic' states result from the failure of normal compensatory antiexcitatory and antioxidant mechanisms to maintain cellular homeostasis.

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Section: The Relation Between Excitatory and Oxidant Eventsmentioning

confidence: 99%