Deprotection and cleavage of peptides bound to Merrifield resin by stable dimethyl ether–poly(hydrogen fluoride) (DMEPHF) complex. a new and convenient reagent for peptide chemistry

8 Natural polymers—chemistry

“…138 Concentrated sulfuric acid in 1,4-dioxane affords an inexpensive and efficient method for the removal of the N-Boc protection on a high load Wang resin, 139 and a dimethyl ether-poly(hydrogen fluoride) complex has been shown to cleave peptides efficiently from Merrifield resins. 140 Microarrays containing thousands of short peptides per cm 2 have been prepared by parallel synthesis on 3-aminopropylsilanized glass, using photolithography and photogenerated acid in the deprotection step of the otherwise conventional Bocprotocol. 141 In addition, immobilization of prefabricated peptides onto an activated support has been successfully applied.…”

An efficient synthesis of isoxepac and 2-ethylanthraquinone via intramolecular acylation catalyzed by chloroaluminate ionic liquids with P2O5

“…Inorganic acids are used as catalysts in traditional processes [1] . In recent years, a variety of activator systems for the acylation of catalyzed carboxylic acids have been developed, including poly-phosphoric acid [2] , hydrogen uoride [3] , tri uoromethanesulfonic acid [4] , mesylate/phosphorus pentoxide [5] , and Lewis acid [6] . Intramolecular acylation is a common reaction in organic synthesis, especially in the synthesis of heterocyclic compounds.…”