Depsides and Other Polar Constituents from Origanum dictamnus L. and Their in Vitro Antimicrobial Activity in Clinical Strains

Chatzopoulou, Aliki; Karioti, Anastasia; Gousiadou, Chrysoula; Vivancos, Vanesa Lax; Kyriazopoulos, Panagiotis; Golegou, Stamatina; Skaltsa, Helen

doi:10.1021/jf904596m

Cited by 61 publications

(37 citation statements)

References 21 publications

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“…In the case of such strains as Salmonella enteritidis and B. cereus, the higher concentration of 400 µg/mL was also insufficient [28]. By contrast, the microbicidal activity of 5 towards Gram-negative Acinetocabter haemolyticus bacteria (MIC = 0.183 mmol/mL) was described by Chatzopoulou et al [29]. Other strains tested by this group, including Empedobacter brevis, P. aeruginosa, and K. pneumonia, were resistant to 5.…”

Section: Discussionmentioning

confidence: 87%

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

Stompor

Żarowska

2016

Molecules

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Abstract:The objective of this study was to evaluate the antimicrobial activity of structural analogues of xanthohumol 1, a flavonoid compound found in hops (Humulus lupulus). The agar-diffusion method using filter paper disks was applied. Biological tests performed for selected strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, fungi (Alternaria sp.), and yeasts (Rhodotorula rubra, Candida albicans) revealed that compounds with at least one hydroxyl group-all of them have it at the C-4 position-demonstrated good activity. Our research showed that the strain S. aureus was more sensitive to chalcones than to the isomers in which the heterocyclic ring C is closed (flavanones). The strain R. rubra was moderately sensitive to only one compound: 4-hydroxy-4'-methoxychalcone 8. Loss of the hydroxyl group in the B-ring of 4'-methoxychalcones or its replacement by a halogen atom (´Cl,´Br), nitro group (´NO 2 ), ethoxy group (´OCH 2 CH 3 ), or aliphatic substituent (´CH 3 ,´CH 2 CH 3 ) resulted in the loss of antimicrobial activity towards both R. rubra yeast and S. aureus bacteria. Xanthohumol 1, naringenin 5, and chalconaringenin 7 inhibited growth of S. aureus, whereas 4-hydroxy-4 1 -methoxychalcone 8 was active towards two strains: S. aureus and R. rubra.

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Section: Discussionmentioning

confidence: 87%

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

Stompor

Żarowska

2016

Molecules

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“…(112) Phytochemical investigation of the polar extracts of the aerial parts of Origanum dictamnus afforded 15 secondary metabolites including naringenin. (113) Bioactive polyphenols including naringenin and naringin were detected in Quercus infusions by HPLC methods. (114) …”

Section: Extraction and Isolation Techniques Of Naringeninmentioning

confidence: 99%

A Review on Pharmacological and Analytical Aspects of Naringenin

Patel

Singh

Patel

2014

Chin. J. Integr. Med.

188

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Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.

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“…Oregano species (except the two Origanum species examined in this study) were reported by the previous literature studies to contain quercetin, apigenin, myricetin, naringenin, kaempferol, rutin, luteolin and coumarin (Skerget et al, 2005;Proestos et al, 2006;Proestos and Komaitis 2008;Ünver et al, 2009;Sellami et al, 2009;Chatzopoulou et al, 2010).…”

Section: Flavonoid Contentsmentioning

confidence: 72%

Antioxidant and antimicrobial activity in the seeds of Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart and Origanum acutidens (Hand.-Mazz.) Ietswaart from Turkey

Kürşat¹,

Emre²,

Yilmaz³

et al. 2011

Grasas y Aceites

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RESUMENEn el presente estudio se han determinado algunos compuestos biológicos (ácidos grasos, vitaminas, esteroles y flavonoides), la capacidad de secuestrar radicales libres y la actividad antimicrobiana de dos especies de orégano, Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart y Origanum acutidens (Hand.-Mazz.) Ietswaart. El ácido linolénico (C 18:3 ) mostró ser el principal ácido graso en ambas especies, seguido por los ácidos palmítico (C 16:0 ), esteárico (C 18:0 ), oleico (C 18:1 n9), linoleico (C 18:2 n6) y estearidónico (C 18:4 ). Además, las dos especies de orégano mostraron contener altos niveles de estigmasterol. También se constató que Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart tenía un elevado contenido de β-sitosterol (152,8  2,6 mg / g), gran cantidad de vitaminas D3 (33,1  0,8 mg / g), K1 (29,4  0,8 mg / g), K2 (26,0  0,8 g / g), y bajos contenidos de α-tocoferol (7,8  0,2 mg / g) y vitamina D2 (1,8  0,1 mg / g), mientras que Origanum acutidens (Hand.-Mazz) Ietswaart contenía altas concentraciones de vitamina D2 (42,9.  1,5 mg / g), y bajas concentraciones de D3 (2,9  0,1 mg / g), α-tocoferol (3,1  0,1 mg / g), γ-tocoferol (3,5  0,2 mg / g), K2 (1.3  0,1 mg / g), acetato de retinol (1,3  0,2 mg / g) y retinol (1,2  0,1 mg / g). El presente estudio también mostró que Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart y Origanum acutidens (mano.-Mazz.) Ietswaart contenían pequeñas concentraciones de flavonoides. Por otra parte, los extractos de metanol mostraron ser el agente más eficaz contra radicales DPPH en ambas especies de orégano examinados. Los resultados experimentales mostraron que las vitaminas, flavonoides y áci-dos grasos de los extractos de ambas especies de orégano fueron eficaces -a diferentes niveles-en la inhibición del crecimiento de los microorganismos ensayados. The present study determined some biological compounds (fatty acids, vitamins, sterols and flavonoids), radical scavenging capacity and antimicrobial activity of two Origanum L. species of Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart and Origanum acutidens (Hand.-Mazz.). Ietswaart. Linolenic acid was found to be the main fatty acid in both species, which was followed by palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1 n9), linoleic acid (C18:2 n6) and stearidonic acid (C18:4). In addition, the two Origanum species were recorded as containing high levels of stigmasterol. It was also found that Origanum vulgare L. subsp. gracile (C. Koch) Ietswaart had a high β-sitosterol content (152.82.6 µg/g); high amounts of D3 (33.10.8 µg/g), K1 (29.40.8 µg/g), K2 (26.00.8 µg/g) vitamins; and low amounts of α-tocopherol (7.80.2 µg/g) and D2 (1.80.1 µg/g), while Origanum acutidens (Hand.-Mazz.) Ietswaart contained high amounts of D2 (42.91.5 µg/g) vitamin; and low amounts of D3 (2.90.1 µg/g), α-tocopherol (3.10.1 µg/g), r-tocopherol (3.50.2 µg/g), K2 (1.30.1 µg/g), retinol (1.30.2 µg/g) and retinol acetate (1.20.1 µg/g) vitamins. The present study showed that O...

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Depsides and Other Polar Constituents from Origanum dictamnus L. and Their in Vitro Antimicrobial Activity in Clinical Strains

Cited by 61 publications

References 21 publications

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

A Review on Pharmacological and Analytical Aspects of Naringenin

Antioxidant and antimicrobial activity in the seeds of <i>Origanum vulgare</i> L. subsp. <i>gracile</i> (C. Koch) Ietswaart and <i>Origanum acutidens</i> (Hand.-Mazz.) Ietswaart from Turkey

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