Abstract-We study joint source-channel coding (JSCC) of compressed sensing (CS) measurements using vector quantizer (VQ). We develop a framework for realizing optimum JSCC schemes that enable encoding and transmitting CS measurements of a sparse source over discrete memoryless channels, and decoding the sparse source signal. For this purpose, the optimal design of encoder-decoder pair of a VQ is considered, where the optimality is addressed by minimizing end-to-end mean square error (MSE). We derive a theoretical lower-bound on the MSE performance, and propose a practical encoder-decoder design through an iterative algorithm. The resulting coding scheme is referred to as channeloptimized VQ for CS, coined COVQ-CS. In order to address the encoding complexity issue of the COVQ-CS, we propose to use a structured quantizer, namely low complexity multi-stage VQ (MSVQ). We derive new encoding and decoding conditions for the MSVQ, and then propose a practical encoder-decoder design algorithm referred to as channel-optimized MSVQ for CS, coined COMSVQ-CS. Through simulation studies, we compare the proposed schemes vis-a-vis relevant quantizers.Index Terms-Vector quantization, multi-stage vector quantization, joint source-channel coding, noisy channel, compressed sensing, sparsity, mean square error.