Dermatological Manifestations of Parkinson's Disease: Clues for Diagnosis

Shahid, Wajeeha; Satyjeet, Fnu; Kumari, Raj; Raj, Kuldeep; Kumar, Vikash; Afroz, Maham Noor; Memon, Muhammad Qasim

doi:10.7759/cureus.10836

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…However, the prevalence rate of our study, 31.2%, is comparably low than the previous documented studies. A study conducted by Shahid et AL., noted seborrhea dermatitis in 56.7% of patients (Shahid et al, 2020). Similarly, in another study 52-54% patients among studied population were diagnosed of seborrhea dermatitis (Arsenijevic et al, 2014).…”

Section: Discussionmentioning

confidence: 53%

Dermatological Issues in Patient With Parkinson’s Disease

PERVAIZ¹,

GULL

MERCHANT

et al. 2022

Pak J Intens Care Med

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To determine the incidence rate of seborrheic dermatitis, bullous pemphigoid, rosacea, and melanoma among the patients diagnosed with Parkinson's Disease. A cross-sectional, observational study. From 13th May 2020 to 13th April 2022 at Bahria International Hospital, Lahore, Pakistan. A total of 80 patients with confirmed Parkinson's disease were evaluated for skin disorders. Disease severity was confirmed through Hoehn Yahr staging criteria (H-Y stage). Skin characteristics and disease diagnosis was made through finding sebum production levels, hot/cold flush test, immunofluorescence, and biopsy evaluation for seborrheic dermatitis, rosacea, bullous pemphigoid, and melanoma, respectively. The test results were compared with the control subject. Chi2 and student t-test was used to find the significance of the results. Out of 80, 44 patients were positive for skin disorders. The incidence of seborrheic dermatitis was found in 31.2% of patients whereas rosacea, bullous pemphigoid, and melanoma were found in 15%, 6.2%, and 2.5% of patients, respectively. Skin disorders are highly prevalent among Parkinson’s disease patients than in the control population. The study invites further research in this area so that the quality of life of patients could be improved.

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Section: Discussionmentioning

confidence: 53%

Dermatological Issues in Patient With Parkinson’s Disease

PERVAIZ¹,

GULL

MERCHANT

et al. 2022

Pak J Intens Care Med

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Cutaneous malignancies in patients with Parkinson’s disease at a dermato-oncological university centre in Hungary

Tóth,

Diakoumakou,

Kuroli

et al. 2023

Front. Oncol.

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BackgroundThe possible correlation between melanoma and Parkinson’s disease (PD) has been intensively studied. In this work, we aimed to assess the coincidence of skin malignancies and PD at a dermato-oncological university centre in Central-Eastern Europe, Hungary.MethodsFrom 2004 to 2017, a retrospective analysis of the centre’s database was performed based on International Statistical Classification of Diseases-10 codes.ResultsOut of the patients who visited the clinic during the study period, 20,658 were treated for malignant skin tumours. Over the 14 years, 205 dermatological patients had PD simultaneously, 111 (54%) of whom had at least one type of skin malignancy: melanoma (n=22), basal cell carcinoma (BCC) (n=82), or squamous cell carcinoma (SCC) (n=36) (in some patients, multiple skin tumours were identified). Compared to the age- and sex-matched control group, patients with PD had a significantly lower risk for basal cell carcinoma (OR, 0.65; 95% CI, 0.47–0.89, p=0.0076) and for all skin tumours (OR, 0.74; 95% CI, 0.56–0.98, p=0.0392) but not for melanoma.ConclusionsWe found a decreased risk of all skin tumours and basal cell carcinoma and an unchanged risk of melanoma among patients with PD. However, it should be kept in mind that some large-scale meta-analyses suggest a higher incidence of melanoma after a diagnosis of PD, indicating the importance of skin examination in this vulnerable population.

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Prevalence and Clinical Significance of Skin Manifestations in Parkinson Disease Patients

Yalçınkaya Iyidal,

Erduran,

Hayran

et al. 2024

Dermatology Practical &Amp; Conceptual

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Background: Parkinson's disease (PD) is primarily characterized by motor symptoms, but non-motor symptoms, including skin manifestations, are increasingly recognized. These remain underexplored despite their potential impact on quality of life. Objectives: This study aimed to evaluate the prevalence and clinical features of skin findings in PD patients, with a focus on identifying potential pathogenetic links between dermatological conditions and PD. Methods: A total of 215 PD patients were included. Comprehensive dermatological examinations were performed, and demographic and clinical data were collected. Statistical analysis was conducted using SPSS 23.0, with significance set at P < 0.05. Results: Skin conditions were found in 92.1% of PD patients. Xerosis, seborrheic dermatitis, and hyperhidrosis were the most common findings. Pre-PD xerosis was associated with an earlier stage of PD (P = 0.001). Use of PD medications, such as levodopa/carbidopa/entacapone, was linked to a lower incidence of seborrheic dermatitis (P = 0.040). A significant correlation was also noted between rosacea and cherry angioma (P = 0.01). Conclusion: Dermatological conditions are prevalent in PD and may precede its motor symptoms. Skin assessments could aid early diagnosis and management of PD, highlighting the need for further research on their pathogenetic mechanisms.

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Dermatological Manifestations of Parkinson's Disease: Clues for Diagnosis

Cited by 4 publications

References 14 publications

Dermatological Issues in Patient With Parkinson’s Disease

Dermatological Issues in Patient With Parkinson’s Disease

Cutaneous malignancies in patients with Parkinson’s disease at a dermato-oncological university centre in Hungary

Prevalence and Clinical Significance of Skin Manifestations in Parkinson Disease Patients

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