Dermatomyositis and malignancy

Vesterager, L; Worm, Anne‐Marie; Thomsen, Kristian

doi:10.1111/j.1365-2230.1980.tb01661.x

Cited by 35 publications

(6 citation statements)

References 8 publications

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“…Of 9 cancer victims among 18 OM patients described by Vesterager et al (19), the mean time from the first consultation for OM to the diagnosis of cancer was only three weeks (1-4 weeks) in five. By cohort analysis, Manchul et al (5) failed to find any increase in the number of subsequent neoplasms in OM-PM patients relative to an age and sex-matched population, although they admitted a markedly high frequency of concurrent malignancy diagnosed within 6 months.…”

Section: Commentmentioning

confidence: 90%

Survey of the Prognosis for Dermatomyositis, with Special Reference to Its Association with Malignancy and Pulmonary Fibrosis

Hidano

Kaneko

Arai

et al. 1986

The Journal of Dermatology

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We sent questionnaires to the major dermatological institutions in Japan concerning the course and associations of dermatomyositis (DM). Of 637 cases observed between 1973 and 1983, 68 were children. The mortality rate was 2.9% in children, 47.1% in adult males, and 30.0% in adult females. Associations with malignancies were noted in 30.1% of adults; 112 cases (19.7% of adults) died from these, but surgery improved the signs of DM in 22 cases. The main neoplasms were cancer of the stomach, lung, colon, and breast. Association with pulmonary fibrosis (PF) was observed in 85 cases (14.9% of adults) and, in spite of intensive treatment, 38 cases (6.7%) died from it. In the majority of PF cases who died within 2 months, pulmonary symptoms started within 6 months of the onset of DM. All cases of PF which occurred before the onset of DM survived. The concurrence of PF and malignancies was exceptional. Death from myocardial disease occurred in only 3 cases.

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Section: Commentmentioning

confidence: 90%

Survey of the Prognosis for Dermatomyositis, with Special Reference to Its Association with Malignancy and Pulmonary Fibrosis

Hidano

Kaneko

Arai

et al. 1986

The Journal of Dermatology

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“…In spite of recent advances in corticosteroid and immunosuppressive therapy, the prognosis is not always favorable. One reason for this poor outcome is the disease's association with internal malignancy; the reported frequency of this complication varies greatly (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Well-controlled statistical studies are needed to determine its relative importance.…”

Section: Introductionmentioning

confidence: 99%

Malignancy and Interstitial Pneumonitis as Fatal Complications in Dermatomyositis

Hidano

Torikai

Uemura

et al. 1992

The Journal of Dermatology

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By sending questionnaires to the major dermatological clinics in Japan, we examined the outcome and causes of death in 182 cases of dermatomyositis (DM) observed between 1983 and 1987. The mortality rate in adults was 26.7%. Associated malignancy occurred in 47 cases (25.8% of adults), and 16 of them died of neoplasms. In contrast to 43 carcinomas, only 1 patient died of lymphoma. Associated interstitial pneumonitis (IP) appeared in 31 cases. IP started simultaneously or within 6 months after the diagnosis of DM in the majority of these cases. Of the 13 fatal cases due to IP, 8 died of respiratory failure within two months of the onset of lung disease. In the malignancy group, periungual erythema was noted in a higher proportion. Raynaud's phenomenon was more frequently noted in the IP group. DM overlapped with other collagen diseases in 14 cases.

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“…The first two cases of DM and malignancy, one of them a breast carcinoma, were described in the second decade of the 20th century (17,21,22). Numerous reports during the following seventy years have shown that DM frequently coexists with a wide spectrum of neoplasticconditions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Nevertheless, the nature of these relationships is not understood (8).…”

Section: Discussionmentioning

confidence: 99%

“…The correlation between dermatomyositis (DM) and malignancy is well documented (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). In most individuals, treatment of neoplastic disease is followed by a remission ofDM (1,8,11,18,19), but, in some patients, such a beneficial effect is less prominent (6,20).…”

Section: Introductionmentioning

confidence: 99%