Description of Insulin Resistance and Beta-Cell Pancreas Dysfunction in Prediabetic Patients

Abstract

Prediabetes is the forerunner of diabetes mellitus. Hence it has to be carefully cared for. Main conditions causing this are insulin resistance and beta cell dysfunction. Insulin resistance can be assessed by using several methods, one of which is performed by assessing the value of HOMA-IR. Beta cell function can be determined by assessing HOMA-B. In this research we aim to obtain the description of insulin resistance and beta cell pancreas dysfunction on prediabetic patients, using the analytic observational method with cross-sectional approach. HOMA-IR and HOMA-B were assessed in 20 prediabetic patients, and their values were obtained by examining basal insulin and fasting glucose level. We found man to woman ratio 1:1, with mean (SD) age 35.8 (5.7) years old, BMI 24.9 (4.3) kg/m2, fasting blood glucose 104.8 (4.3) mg/dL, and blood glucose two hours after oral glucose tolerance test 121.7 (23.1) mg/dl. Mean of HOMA-IR on prediabetic patients was 4.1 (3.2) and mean of HOMA-B was 188.3 (155.1). The increase of insulin resistance on this study is by studies that were conducted by Nguyen and Mohtarin. The increase of HOMA-B in this study is following other studies by Mohtarin and Owei, supposedly due to beta cell compensation process against the increase of insulin resistance. We conclude that the increase of HOMA-IR in prediabetics is compensated for by an increase in HOMA-B.

Pengaruh Senam Prolanis Terhadap Penurunan Kadar Gula Darah Pada Penderita Diabetes Melitus Di Kelurahan Nangsri Kebakkramat

“…Progressive, Endurance Training). Beberapa olahraga yang disarankan antara lain jalan atau lari pagi, bersepeda, berenang, dan senam (Decroli, 2019).…”

Correlation between Insulin Resistance with Soluble CD40 Ligand and Plasminogen Activator Inhibitor-1 Plasma in Pre-diabetic Patients

“…The International Diabetes Federation in 2019 reported that the prevalence of pre-diabetes was 373.9 million or 7.5% of the adult population aged 20-79 years worldwide. In Indonesia, there was 29.1 million population with prediabetes in 2019 [1], [2], [3], [4].…”

“…HOMA-IR can describe insulin resistance. Decroli et al stated that increased insulin secretion compensates for increased HOMA-IR by beta-cell pancreas in pre-diabetic patients [4], [5], [6], [7]. Various studies have proven that in pre-diabetic patients, a prothrombotic state has taken place, which will cause micro-and macro-vascular complications [8], [9], [10], [11], [12].…”