This study aimed to evaluate the Effort-Reward Imbalance among nurses and its association with burnout syndrome. This is an observational study of a cross-sectional type. A self-administered survey was used to collect the socio-demographic and professional characteristics. The Siegrist Effort-Reward Imbalance scale to measure the psychosocial risks and the Copenhagen Burnout Inventory to assess burnout. The results indicate that the level of burnout is moderate [patient-related burnout (2.77±0.95), general burnout (3.00±0.67)], but there is an imbalance between the efforts and rewards received by nurses (1.50±0.51). The indices calculated by Cronbach’s alpha are very important for effort (α=0.79), and reward (α=0.75). The results raise questions about the importance of a better understanding of the effect of psychosocial risks on health through perceived effort/reward. The use of information and communication technologies to accurately identify psychosocial risks at work is recommended.