Design and Analysis of a Laminar Diffusion-Based Micromixer with Microfluidic Chip

Abstract

This study aims to perform optimizatione to achieve the best diffusion control between the channels by designing and analysing a microfluidic-based micromixer. The design and analysis of the micromixer were made with the COMSOL Multiphysics program. Some input and output parameters must be defined for diffusion control of the micromixer. Among these parameters, inputs are the diffusion coefficient and inlet flow rate, while outputs are velocity, pressure, and concentration. Each input parameter in the microfluidic chip affects the output of the system. To make the diffusion control in the most optimum way, the data were obtained by making much analysis. The data obtained from this program was also provided with the Fuzzy Logic method to optimize the microfluidic chip. The diffusion coefficient value (5E-11 m2/s) should be given to the channels to achieve the optimum diffusion between the micromixer channels, if the inlet flow rate value (15E-15 m3/s) is the output value of the system, the velocity is 0.09 mm/s. The pressure is 2 Pa, and the concentration is 0.45 mol/m3. These values are the optimum values obtained from the analysis without damaging the liquid’s microfluidic channels supplied to the micromixer’s inlet.

[Retracted] Application of CFD Numerical Simulation Image Imaging Technology in the Study of Droplet Microfluidic Multiphase Flow Characteristics

“…After the organic phase and aqueous phase formed a stable laminar flow, the selective extraction of a variety of ions was realized based on the selective difference between the ions of neutral ion carrier and the extract. Then, the ions were measured downstream of the organic phase by thermal lens microscope under continuous flow conditions [ 9 ]. Subsequently, Ahmed et al constructed a three-phase flow microfluidic extraction device in the microchannel (150 μ m × 25 μ m) on the glass microchip (3 cm × 7 cm) and used it as a liquid membrane to separate the spontaneous phase separation of the three-phase flow in the microfluidic device caused by the surface modification of the microchannel by octadecylsilane groups.…”

How to Control the Microfluidic Flow and Separate the Magnetic and Non-Magnetic Particles in the Runner of a Disc

“…Compared with real flow experiments, it is possible to investigate to determine the optimal design patterns for the disc by CAE software. It is also possible to correct and avoid potential design errors by computing the outcome of the microfluidic flow [20,21]. Therefore, this study used Ansys Fluent R15.0 to create the optimal pattern design of the disc.…”

“…Differences in the disturbance of the microfluidic were difficult to observe or analyze when the mi-crofluidic flow was in the mixing runner of the spanned disc. As flow lasts too short, they are laminar flow [21]. Therefore, several different curve angles were designed for mixing the runners to simulate whether they would have different transient disturbances with the microfluidic flow into the mixing runner.…”

Flexible Materials for High-Resolution 3D Printing of Microfluidic Devices with Integrated Droplet Size Regulation

“…This procedure can take up to several days depending on the experimental skills of the user and the available infrastructure, before a functional microfluidic device is obtained. Despite the multitude of applications of microfluidics in sensing, − cell culturing, − sorting and mixing, , high-throughput drug screening, − or the preparation of emulsions and vesicles, this multistep fabrication process is one major reason that has long limited the commercial breakthrough of microfluidics. On this account, additive manufacturing techniques have started to revolutionize the fabrication of microfluidic devices due to the freedom of digital design and, under ideal conditions, the one-step processability of starting materials such as polymer melts, hydrogel precursors, or photopolymer formulations (resins). − Especially, digital light processing (DLP)-based 3D printing or projection microstereolithography (PμSL) exhibits a number of promising features that may soon replace well-established techniques for microfluidic device fabrication.…”