Design and application of molecularly imprinted Polypyrrole/Platinum nanoparticles modified platinum sensor for the electrochemical detection of Vardenafil

Ahmed, Riham K.; Saad, Engy M.; Fahmy, H. M.; Nashar, Rasha M. El

doi:10.1016/j.microc.2021.106771

Cited by 27 publications

(15 citation statements)

References 78 publications

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“…As for reproducibility, it can be correlated to the possibility of getting the same measurement results on applying an analytical approach at variable operational conditions that may involve different instruments, or vendor of reagents or even the analyst performing the measurement or its time and/or place. Thus, three different electrodes were applied for testing the same Saxa solution on different days with a RSD of 1.04 % indicating the acceptable reproducibility of the proposed method [69,80]. The sensor can be successfully stored for 30-40 days at room temperature without any change in its efficiency, the response was found to decrease to around 95 % after further storage, this indicates the reasonable shelf stability and applicability of the proposed sensor.…”

Section: Repeatability and Reproducibility Of The Sensormentioning

confidence: 75%

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

et al. 2023

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Saxagliptin (Saxa) belongs to a new generation of antidiabetic pharmaceutical compounds used in combination with healthy diet and exercise to lower blood glucose levels in patients with type 2 diabetes mellitus (T2DM). In this work, we report for the first time a molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of Saxa. Computational calculations were performed, based on which five MIPs were synthesized using Saxa as a template, itaconic acid as a monomer, crosslinked with ethylene glycol dimethacrylate and Di methyl sulfoxide (DMSO) as a porogen with different ratios. Non‐covalent interaction (NCI) analysis has been also conducted, and the obtained isosurface analysis was used for graphical visualization of NCI that could occur in real space as well as for the discrimination between hydrogen bond interaction, Van Der Waals attraction and spatial repulsion. The optimized polymer was incorporated as a modifier for designing an electrochemical sensor comprising MIP and Multiwalled carbon nanotubes (MwCNT) within carbon paste electrode (CPE). The operational variables including incubation time, pH, scan rate, and accumulation time were optimized. The sensor showed linearity over the concentration range (1 × 10−9–1 × 10−15 M) with low limit of detection (LOD) 8 × 10−16 and 2 × 10−16 M on using DPV and EIS, respectively. The sensor was successfully applied for pharmaceutical formulations, urine, and human serum samples with recovery range between 97.45–100.64 %.

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Section: Repeatability and Reproducibility Of The Sensormentioning

confidence: 75%

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

et al. 2023

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“…1A. 38 An increase in the current response was noticed on increasing the number of cycles of the electropolymerization process, indicating the formation of a conducting film of poly (CR).…”

Section: Resultsmentioning

confidence: 93%

“…57,58 Repeatability, which describes the ability of a technique to give the same result at the same conditions of the measurement, 59,60 was examined for AuNPs/poly(CR)/GCE by recording six successive DPV determinations of 1 μM FAM using the same sensor and the relative standard deviation (RSD) of the results obtained was found to be 2.63%. While reproducibility, representing the possibility of getting the same results of a measurement on changing the time and/ or the place of the measurement was verified for AuNPs/poly(CR)/ GCE through preparing three different modified sensors, 38,61 followed by testing their DPV response for a solution that is 100 μM FAM, and the RSD was found to be 1.51%. These results indicated that the presented sensor has efficient reproducibility, and the obtained data were repeatable at different operational times and places.…”

Section: Resultsmentioning

confidence: 94%

Application of a Gold /Poly(Congo Red) Modified Electrochemical Sensor Toward Fast and Reliable Detection of the Oxazolidinone Fungicide Famoxadone in Vegetables

Benhawy¹,

Fahmy²,

ElDien³

et al. 2023

J. Electrochem. Soc.

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The synthesis and optimization of an electrochemical sensor based on gold nanoparticles (AuNPs)/ conducting poly Congo red dye (poly(CR)) nanocomposite is reported for the detection of the Oxazolidinone fungicide famoxadone (FAM), an environmentally hazardous material. The modification of a glassy carbon electrode (GCE) was performed using cyclic voltammetry (CV) to deposit poly(CR) while AuNPs were deposited using chronoamperometry. Two linear ranges 0.001 – 1 µM (0.37 – 374.40) µg/L and 3 – 100 µM (1.12 – 37.44) mg/L were recorded using AuNPs/poly (Congo Red)/GCE sensor for FAM with limit of detection (LOD) of 0.17 nM (0.06 µg/L) and limit of quantification (LOQ) of 0.48 nM (0.18 µg/L). The tested sensor showed good stability, reproducibility, and repeatability. in addition, sufficient selectivity towards FAM in the presence of other tested pesticides was shown. Finally, the fabricated sensor was applied for the determination of FAM in vegetables and commercial fungicides formulation, with a recovery range 98.9 - 105.4% and RSD 0.70– 4.46%, which represents its efficiency in comparison with previously reported chromatographic methods.

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“…With different working electrodes, including platinum, different techniques can be used to remove the imprinted material. Various solvents are often used to remove bacteria, for instance, acetic acid, hydrochloric acid, other acids, methanol, and mixtures of those solvents [ 32 , 34 , 43 ]. Although challenging, extraction of the bacteria from the polymer is essential for forming the MIPs [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Towards Electrochemical Sensor Based on Molecularly Imprinted Polypyrrole for the Detection of Bacteria—Listeria monocytogenes

et al. 2023

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Detecting bacteria—Listeria monocytogenes—is an essential healthcare and food industry issue. The objective of the current study was to apply platinum (Pt) and screen-printed carbon (SPCE) electrodes modified by molecularly imprinted polymer (MIP) in the design of an electrochemical sensor for the detection of Listeria monocytogenes. A sequence of potential pulses was used to perform the electrochemical deposition of the non-imprinted polypyrrole (NIP-Ppy) layer and Listeria monocytogenes-imprinted polypyrrole (MIP-Ppy) layer over SPCE and Pt electrodes. The bacteria were removed by incubating Ppy-modified electrodes in different extraction solutions (sulphuric acid, acetic acid, L-lysine, and trypsin) to determine the most efficient solution for extraction and to obtain a more sensitive and repeatable design of the sensor. The performance of MIP-Ppy- and NIP-Ppy-modified electrodes was evaluated by pulsed amperometric detection (PAD). According to the results of this research, it can be assumed that the most effective MIP-Ppy/SPCE sensor can be designed by removing bacteria with the proteolytic enzyme trypsin. The LOD and LOQ of the MIP-Ppy/SPCE were 70 CFU/mL and 210 CFU/mL, respectively, with a linear range from 300 to 6700 CFU/mL.

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Design and application of molecularly imprinted Polypyrrole/Platinum nanoparticles modified platinum sensor for the electrochemical detection of Vardenafil

Cited by 27 publications

References 78 publications

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

Application of a Gold /Poly(Congo Red) Modified Electrochemical Sensor Toward Fast and Reliable Detection of the Oxazolidinone Fungicide Famoxadone in Vegetables

Towards Electrochemical Sensor Based on Molecularly Imprinted Polypyrrole for the Detection of Bacteria—Listeria monocytogenes

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