Design and construction of a magnetic resonance compatible multi-injector gas jet delivery system

Megı́as-Alguacil, David; Keller, Thierry; Lutz, Kai; Barlow, Ashley; Ettlin, Dominik A

doi:10.1063/1.2823329

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…To overcome these issues with questionnaires and since a split‐mouth design was chosen in this study, a modified portable version of a recently developed air puff stimulator was used (Megias‐Alguacil et al. , D.A. Ettlin, T. Hitz, T., C.F.…”

Section: Discussionmentioning

confidence: 99%

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Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Thoma

Sancho-Puchades

Ettlin

et al. 2011

J Clinic Periodontology

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Section: Discussionmentioning

confidence: 99%

“…To standardize and quantify somatosensory measurements, a modified portable version of an air jet delivery system was used for stimulation of the intra-oral mucosa (Megias-Alguacil et al 2008, D.A. Ettlin, T. Hitz, T., C.F.…”

Section: Somatosensory Measurementsmentioning

confidence: 99%

Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Thoma

Sancho-Puchades

Ettlin

et al. 2011

J Clinic Periodontology

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“…For example, a cotton swab (diameter 10 mm) can repeatedly be brushed over a painful facial or intra‐oral region and the contralateral side for 10 s at about 2 Hz, and the increase in pain, if any, be assessed on a 0–10 VAS (79). A computer‐controlled automated air jet stimulator with a flow range from 2 to 20 L min −1 has recently been developed primarily for QST of intra‐oral mucosal wounds, as stimulation is possible without tissue contact (89). A modified portable version has recently been tested for assessment of oral wound sensitivity (90).…”

mentioning

confidence: 99%

Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions - a taskforce report

Svensson

Baad‐Hansen

Pigg

et al. 2011

Journal of Oral Rehabilitation

174

203

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Summary The goals of an international taskforce on somatosensory testing established by the Special Interest Group of Oro-facial Pain (SIG-OFP) under the International Association for the Study of Pain (IASP) were to (i) review the literature concerning assessment of somatosensory function in the oro-facial region in terms of techniques and test performance, (ii) provide guidelines for comprehensive and screening examination procedures, and (iii) give recommendations for future development of somatosensory testing specifically in the oro-facial region. Numerous qualitative and quantitative psychophysical techniques have been proposed and used in the description of oro-facial somatosensory function. The selection of technique includes time considerations because the most reliable and accurate methods require multiple repetitions of stimuli. Multiple-stimulus modalities (mechanical, thermal, electrical, chemical) have been applied to study oro-facial somatosensory function. A battery of different test stimuli is needed to obtain comprehensive information about the functional integrity of the various types of afferent nerve fibres. Based on the available literature, the German Neuropathic Pain Network test battery appears suitable for the study of somatosensory function within the oro-facial area as it is based on a wide variety of both qualitative and quantitative assessments of all cutaneous somatosensory modalities. Furthermore, these protocols have been thoroughly described and tested on multiple sites including the facial skin and intra-oral mucosa. Standardisation of both comprehensive and screening examination techniques is likely to improve the diagnostic accuracy and facilitate the understanding of neural mechanisms and somatosensory changes in different oro-facial pain conditions and may help to guide management. assessments of all cutaneous somatosensory modalities. Furthermore, these protocols have been thoroughly described and tested on multiple sites including the facial skin and intraoral mucosa.Standardization of both comprehensive and screening examination techniques is likely to improve the diagnostic accuracy and facilitate the understanding of neural mechanisms and somatosensory changes in different orofacial pain conditions and may help to guide management.

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“…A modified version of the previously developed multi-injector AJS was used that consists of four computer-controlled channels of which three were used for the CASA (Megias-Alguacil et al, 2008 ). This system is able to apply air flow rates between 0.3 and 20 l/min in steps of 0.1 l/min.…”

Section: Methodsmentioning

confidence: 99%

Novel Air Stimulation MR-Device for Intraoral Quantitative Sensory Cold Testing

Brönnimann

Meier

Hou

et al. 2016

Front. Hum. Neurosci.

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The advent of neuroimaging in dental research provides exciting opportunities for relating excitation of trigeminal neurons to human somatosensory perceptions. Cold air sensitivity is one of the most frequent causes of dental discomfort or pain. Up to date, devices capable of delivering controlled cold air in an MR-environment are unavailable for quantitative sensory testing. This study therefore aimed at constructing and evaluating a novel MR-compatible, computer-controlled cold air stimulation apparatus (CASA) that produces graded air puffs. CASA consisted of a multi-injector air jet delivery system (AJS), a cold exchanger, a cooling agent, and a stimulus application construction. Its feasibility was tested by performing an fMRI stimulation experiment on a single subject experiencing dentine cold sensitivity. The novel device delivered repetitive, stable air stimuli ranging from room temperature (24.5°C ± 2°C) to −35°C, at flow rates between 5 and 17 liters per minute (l/min). These cold air puffs evoked perceptions similar to natural stimuli. Single-subject fMRI-analysis yielded brain activations typically associated with acute pain processing including thalamus, insular and cingulate cortices, somatosensory, cerebellar, and frontal brain regions. Thus, the novel CASA allowed for controlled, repetitive quantitative sensory testing by using air stimuli at graded temperatures (room temperature down to −35°C) while simultaneously recording brain responses. No MR-compatible stimulation device currently exists that is capable of providing non-contact natural-like stimuli at a wide temperature range to tissues in spatially restricted areas such as the mouth. The physical characteristics of this novel device thus holds promise for advancing the field of trigeminal and spinal somatosensory research, namely with respect to comparing therapeutic interventions for dentine hypersensitivity.

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Design and construction of a magnetic resonance compatible multi-injector gas jet delivery system

Cited by 5 publications

References 20 publications

Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Guidelines and recommendations for assessment of somatosensory function in oro-facial pain conditions - a taskforce report

Novel Air Stimulation MR-Device for Intraoral Quantitative Sensory Cold Testing

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