Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics

Seelan, T. Veenus; Henry, Linda Jeeva Kumari; Kishore, Narra; Pachuau, Lalduhsanga; Kandasamy, Ruckmani

doi:10.1016/j.ijbiomac.2016.08.006

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…Nowadays, tablet is still among the favorite forms of commercial drugs for treating diseases [11][12][13].It has used to Carr's plant extract to be used as an anti-microbial agent, supplement and even as an anti-cancer agent [14][15][16]. Tablets are obtained from the aggregation of powder by applying pressure during the process.…”

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confidence: 99%

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Irawaty

Hadisoewignyo

Wijaya

et al. 2019

EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT: Proceedings of the 5th International Conference on E

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Dried kaffir lime peels from Citrus hystrix were extracted with ethanol by maceration method, followed by solvent evaporation to obtain dry extract. Due to economical aspect and good flow properties of the extract, a direct compression method was applied in making the tablets. The main objective of this study was to study the influence of filler-binder (Avicel PH 102, Emcompress and Lactose) on rheological properties of kaffir lime peel extract tablet dough. Firstly, kaffir lime peel extract was prepared by peeling, cutting and drying kaffir lime peels prior to soaking them to ethanol. After separating the solid part, the extract was subsequently concentrated and filler was added into the crude extract to obtain dry product. Secondly, dry extract was then combined with filler-binder, sweetener and lubricant prior to the compression. Rheological properties evaluated in this study were density, flow time, the Carr index and the Hausner ratio. Thirdly, the best formulation dough was compressed to produce tablets. From the results, it can be concluded that ethanol is the best solvent to extract polyphenols from kaffir lime peels. In addition, the use of a mixture of lactose and Avicel PH 102 as the filler-binder agent exhibited the best formulation.

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Section: -1mentioning

confidence: 99%

Design of kaffir lime peel extract tablets by direct compression: Effects of filler-binder on rheological properties

Irawaty

Hadisoewignyo

Wijaya

et al. 2019

EXPLORING RESOURCES, PROCESS AND DESIGN FOR SUSTAINABLE URBAN DEVELOPMENT: Proceedings of the 5th International Conference on E

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“…The voucher no. of bark material was 33,18 . The Stem bark was cut, cleaned, and dried completely under shade to eliminate moisture content.…”

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2022

IJPSR

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The present research effort was undertaken to isolate phytoconstituents from pharmacologically active extracts of stem bark of Albizia stipulata based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of bark of Albizia stipulata were prepared using various solvents such as methanol, hydro alcohol, and water. These extracts were screened for in-vitro pharmacological activities like antioxidant, anti-inflammatory, and anti-diabetic activities. The active extract was subjected to column chromatography through a mixture of solvents to get fractions and eluted fractions were run in TLC using various mobile phases with different solvent ratios. The isolated compounds were subjected to IR, 1H NMR, 13CNMR and LC-MS spectral analysis for chemical characterization. Results: The methanol extract of bark of Albizia stipulata was potent compared to other extracts. This extract was subjected to column chromatography to get fractions, and eluted fractions were run in TLC. The fractions with similar R f values to standard were united and crystallized. The spectral analysis confirmed that the isolated compounds were found to be β-Sitosteryl-3-O-β-D-glucoside and 3 -O methyl D-Chiro Inositol. Conclusion: Various extracts from the bark of the plant Albizia stipulata were prepared. Β-sitosteryl-3-O-β-D-glucoside and 3-O methyl D-Chiro Inositol were isolated from the methanol extract of bark and characterized. INTRODUCTION: Herbs used in Ayurveda offer biologically active molecules and lead structures for modification.

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