Design and development of fluoxetine hydrochloride oro flash films to alleviate major depressive disorder

Abstract

The current research concerns the development of the formulation of fluoxetine HCl (anti-depressant) oro flashes the new prospective by using solvent casting method. Oro flashes are quick dissolving oral films and the materials used were hydrophilic. Fluoxetine HCl formulations were developed since oro flashes improves bioavailability to attain onset of action, along with the patient compliance. Fluoxetine HCl is used to treat major depressive disorder, bulimia nervosa (an eating disorder), obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Polyvinyl alcohol (PVA) undergoes polymerization and forms oro flash film. Five different formulations were developed by using different polymeric concentrations of PVA. Polyvinyl pyrollidone K30 (PVP K30) used as super disintegrating agent and plasticizer, whereas menthol and mannitol were used as sweetener, flavoring agent respectively and water as a solvent system. In the study five formulations (F1, F2, F3, F4, and F5) were evaluated for the properties such as thickness, folding endurance, drug content uniformity, surface pH, in vitro disintegration time, dissolution studies, % moisture loss, % moisture uptake, weight variation test, conductivity test. Results revealed that, F3 formulation can be considered as best, which has morphological features are homogenous and transparent with optimum thickness 0.23 ± 0.02 lm, folding endurance ([250 times number of folds on the same crease), drug content uniformity (k max at 225 nm) 97.60 ± 1.28, surface pH 6.654 ± 0.020, in vitro disintegration time 11 ± 1.20 s, in vitro dissolution studies 97.30 ± 0.75 %, % moisture loss 5.021 ± 0.052 %, % moisture uptake 3.634 ± 0.102 %, weight variation test 48.74 ± 1.0, conductivity test 61 lS which has maximum drug release (97.3 %) which facilitates maximum bioavailability.

Nanoporous and nano thickness film-forming bioactive composition for biomedical applications

“…The developed NFRCS were experimented with Fourier transform infrared (FTIR) spectroscopy (Shimadzu 8400 s FTIR, Tokyo, Japan) to confirm the chemical compatibility of chitosan with other polymers 14 , 15 . The FTIR spectrum of all test samples was obtained by executing 32 scans (spectral range width of 400 to 4000 cm -1 ).…”

Design and development of tranexamic acid loaded film‐forming gel to alleviate melasma

“…the spectrums were acquired by executing 32 scans. 8 The obtained spectral values compared with the pure drug TXA and compatibility of the drug with excipients were determined.…”

“…The percentage moisture loss was determined using the following formula. 8 where W 1 is the amount of FFG taken for the study, and W 2 is the dry weight of the film formed by FFG.…”

“…The films placed in the desiccator were reweighed after one day, the percentage of moisture uptake was estimated using the following formula. 8 The average of three trials was considered as a percentage of moisture uptake.…”

Desenvolvimento de matrizes poliméricas como veículo de ácido ascórbico: caracterização e avaliação da estabilidade

“…Diversos trabalhos disponíveis na literatura reportam a utilização da técnica de casting para a produção de filmes de desintegração oral (REPKA et al, 2005;CILURZO et al, 2008;GHORWADE et al, 2011;SAPKAL et al, 2011;MANHAR et al, 2013;JANßEN et al, 2013;MUZIBI et al, 2013;SAYED et al, 2013;MARQUES et al, 2014;BORGES et al, 2015;CHAVALA et al, 2015;ZHANG et al, 2015) Cilurzo et al (2008) Polietilenoglicol, glicerol Brniak et al (2015) Álcool polivinílico Chevala et al (2015) Glicerol Haque e Sheela (2015)…”