Design and Evaluation of a Hybrid Mock Circulatory Loop for total Artificial Heart Testing

Abstract

The hybrid MCL that we developed allows variable and continuous in vitro evaluation of mechanical circulatory support devices in TAH configuration and particularly their control algorithms in response to various cardiovascular conditions. The system has been built in a modular configuration to allow testing of different types of devices and thus provides a valuable test platform prior to animal experiments.

Novel Optical Position Sensing for Miniaturized Applications and Validation in a Total Artificial Heart

“…The system was already described in [14], [15]. For this test, a complete ReinHeart TAH was used, including the pump chambers and a TAH-controller.…”

Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank–Starling Mechanism and Baroreflex

“…3. The effect of afterload manipulation was performed by reducing SVR values from 3550 to 1310 dynes·s/ cm 5 in steps of 320 dynes·s/cm 5 (Fig. 3a was performed during test medium reduction of 600 mL inside the MHCLAUTO, resulting in a change in the MLAPdiast from 11 to 7 mm Hg in 0.5 mm Hg steps.…”

“…Lately, hybrid MHCLs were developed to simulate the native physiologic hemodynamics (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). With a numeric-hydraulic interface, and so-called "Hardware in the Loop" (HIL) concept, control mechanisms and the hydraulic components of the MHCL are brought together.…”

“…Brunberg et al based on Ursino et al(24,25). HR and Emax were fitted to the requirements of the MHCLAUTO given in Equation5. The BR model used in the MHCLAUTO simulates only the dominating carotid baroreceptors.…”

“…To apply this to the MHCLAUTO it was refined by Cuenca-Navalon et al and converted into a Simulink S-function (Mathworks, Inc., Natick, USA) for real time interaction with the MHCLAUTO software (5). Identical time constant was used for the Dymola model and the MHCLAUTO for all the experiments(5,23). The mean aortic pressure (MAP) inFig.…”