Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering

Singh, B. N.; Veeresh, Vivek; Mallick, Sarada Prasanna; Jain, Yogesh; Sinha, Shivam; Rastogi, Amit; Srivastava, Pradeep

doi:10.1016/j.ijbiomac.2019.04.107

Cited by 104 publications

(47 citation statements)

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“…The XRD pattern observed is similar to that shown in a previous study and is characterized by broad diffraction bands [26]. Amorphous nanosized bioglass has the ability to promote apatite deposition under physiological conditions [27]. In Figure 2b, the diffraction peaks could be characteristic of those found in nature, according to Joint Committee on Powder Diffraction Standards (JCPDS) File No.…”

Section: Discussionsupporting

confidence: 81%

Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

et al. 2020

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Featured Application: Bioactive glass proposed in this study demonstrated its possibility as a drug delivery system based on its nanoporous structure and bioactivity for biomedical application.Abstract: Bioactive glass (BG) was made by the sol-gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer-Emmett-Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system.

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Section: Discussionsupporting

confidence: 81%

Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

et al. 2020

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“…Hence, the pore sizes of the nHD scaffolds were suitable for bone tissue engineering application, which were in accordance with previous studies about bone regeneration scaffolds [34,37]. Furthermore, the porosities of the composite scaffolds are also crucial elements for fabricating suitable scaffolds for bone tissue regeneration [34]. As shown in Figure 5B, the porosities of the nHD-1, nHD-2 and nHD-3 scaffolds were 75.2% ± 2.21%, 82.3% ± 3.15% and 83.5% ± 3.78%, respectively.…”

Section: Structure Of the Scaffolds Before And After Enzymatic Degradsupporting

confidence: 90%

“…On the contrary, if the pore size is too large, this may affect the mechanical property of scaffolds and the production of extracellular matrix on scaffolds [35,36]. Hence, the pore sizes of the nHD scaffolds were suitable for bone tissue engineering application, which were in accordance with previous studies about bone regeneration scaffolds [34,37]. Furthermore, the porosities of the composite scaffolds are also crucial elements for fabricating suitable scaffolds for bone tissue regeneration [34].…”

Section: Structure Of the Scaffolds Before And After Enzymatic Degradsupporting

confidence: 82%

“…The hole diameters of the three scaffolds were approximately 150 to 360 μm, which is beneficial for cell growth and nutrient exchange. The smaller average pore size (<100 μm) can interfere with cell distribution and restricts cell migration to the center of scaffolds [34,35]. On the contrary, if the pore size is too large, this may affect the mechanical property of scaffolds and the production of extracellular matrix on scaffolds [35,36].…”

Section: Structure Of the Scaffolds Before And After Enzymatic Degradmentioning

confidence: 99%

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Fabrication of High-Strength and Porous Hybrid Scaffolds Based on Nano-Hydroxyapatite and Human-Like Collagen for Bone Tissue Regeneration

Liu

Fan

2020

Polymers

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A novel, three-dimensional, porous, human-like collagen (HLC)/nano-hydroxyapatite (n-HA) scaffold cross-linked by 1,2,7,8-diepoxyoctane (DEO) was successfully fabricated, which showed excellent mechanical and superior biological properties for bone tissue regeneration in this study. The physicochemical characterizations of different n-HA/HLC/DEO (nHD) scaffolds were investigated by determining the morphology, compression stress, elastic modulus, Young’s modulus and enzymatic hydrolysis behavior in vitro. The results demonstrated that nHD-2 and nHD-3 scaffolds showed superior mechanical properties and resistance to enzymatic hydrolysis compared to nHD-1 scaffolds. The cell viability, live cell staining and cell adhesion analysis results demonstrated that nHD-2 scaffolds exhibited low cytotoxicity and excellent cytocompatibility compared with nHD-1 and nHD-3 scaffolds. Furthermore, subcutaneous injections of nHD-2 scaffolds in rabbits produced superior anti-biodegradation effects and histocompatibility compared with injections of nHD-1 and nHD-3 scaffolds after 1, 2 and 4 weeks. In addition, the repair of bone defects in rabbits demonstrated that nHD-2 scaffolds presented an improved ability for guided bone regeneration and reconstruction compared to commercially available bone scaffold composite hydroxyapatite/collagen (HC). Collectively, the results show that nHD-2 scaffolds show promise for application in bone tissue engineering due to their excellent mechanical properties, anti-biodegradation, anti-biodegradation, biocompatibility and bone repair effects.

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“…The polycationic nature of CS provides the possibility of designing polyelectrolyte complexes with polyanionic polymers to improve the mechanical properties of composite scaffolds [15,66]. In one study, CS/chondroitin/nano-bioglass-based polyelectrolyte composite material was developed with improved bioactivity, such as accumulation of apatite and increased expression of type-1 collagen by MG63 osteoblast-like cells in vitro and with osteointegration of the scaffold in vivo [67]. CS possesses active biomineralization properties and these could be further increased by introducing other polymers such as fucoidan [17,68] and bioglass [69].…”

Section: Bonementioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

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Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering

Cited by 104 publications

References 50 publications

Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

Fabrication of High-Strength and Porous Hybrid Scaffolds Based on Nano-Hydroxyapatite and Human-Like Collagen for Bone Tissue Regeneration

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

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