Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method

Nirmala, Dasari; Nandhini, S.; Sudhakar, M.

doi:10.5958/2231-5691.2016.00012.5

Cited by 17 publications

(4 citation statements)

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“…Physical characterization studies: Thickness, folding endurance, tensile strength and percentage elongation were studied as per the procedures reported by Bansal S et al [16] and Nirmala D et al [17] Drug content: An ODF of 25 cm 2 as casted was taken and placed in a beaker containing 80 mL of the dissolution medium i.e., 10 mM potassium phosphate buffer containing 0.0075 mg/mL butylated hydroxytoluene and 1.5% tween 80 with pH 6.0. This was placed in a rotary shaker and periodically samples were withdrawn and subjected to spectrophotometry.…”

Section: In Vitro Characterization Studies Of the Odfsmentioning

confidence: 99%

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Amorphous solid dispersion of ledipasvir and sofosbuvir for enhancement of oral bioavailability

Kumar THUMMALA,

MADDI,

AVULA

2023

jrp

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The major goal of this research work was to augment bioavailability of the fixed-dose combination drugs, ledipasvir (LDV) and sofosbuvir (SBV) by developing orodispersible tablets and films and to estimate it by in vivo pharmacokinetic studies in rats. The pre-optimized amorphous solid dispersions of the LDV-SBV combination with HPMC E15 were made into orodispersible films (ODFs) and the pre-optimized inclusion complexes with dimethyl-βcyclodextrin were made into orodispersible tablets (ODTs). The ODFs and ODTs were studied for the in vitro physical characterization studies and dissolution. Best of both the products were evaluated for in vivo pharmacokinetic studies in comparison with the marketed formulation of film coated tablets, Ledifos. The dissolution rate constants for the LDV from the optimized ODFs, ODTs and the marketed tablets were found to be 0.269, 0.13 and 0.073 min.-1 respectively. The dissolution rate constants for the SBV from the optimized ODFs, ODTs and the marketed tablets were found to be 0.302, 0.168 and 0.094 min.-1 respectively. Area under the curve (AUC) values for the LDV from the films, tablets and the marketed tablets were found to be 4231.4, 4050.3 and 3662.5 h*ng/mL respectively. AUC values for the SBV from the films, tablets and the marketed tablets were found to be 2173.2, 2084.6 and 1452.4 h*ng/mL respectively. Conclusion: The obtained results indicated that the optimized ODFs and the ODTs exhibited improved in vitro dissolution and in vivo bioavailability for the fixed-dose combination of LDV and SBV over the reference product.

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Section: In Vitro Characterization Studies Of the Odfsmentioning

confidence: 99%

“…The obtained samples were quantified after suitable dilutions for both the LDV and SBV using spectrophotometer. The data obtained was fitted to zero-order and first-order kinetic models to identify the order of dissolution kinetics and also to calculate T90% values [17].…”

Section: In Vitro Characterization Studies Of the Odfsmentioning

confidence: 99%

Amorphous solid dispersion of ledipasvir and sofosbuvir for enhancement of oral bioavailability

Kumar THUMMALA,

MADDI,

AVULA

2023

jrp

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“…Moister Contain (Nirmala et al, 2016) The prepared films were weighed and stored at room temperature in a vacuum desiccator containing anhydrous silica. The film was measured several times until it indicated a stable weight.…”

Section: Folding Endurancementioning

confidence: 99%

Fast Dissolving Films: Brief review on preparation methods, ingredients and technology used

Mehta¹,

Patil²,

Patil³

et al. 2021

Adv Pharm J

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The Oral fast dissolving drug delivery system is defined as dissolved or disintegration in few seconds or within a few minutes hold in the mouth without water and swallowing. In recent years oral fast dissolving films is promising drug delivery system due to several advantages for pediatric and geriatric patient who have trouble to swallowing conventional oral dosage types. over few decades fast disintegrating tablets have gained significant attention alternative to conventional tablet and capsule due to good patient compliance FDTs are solid dosage form which is rapidly disintegrate usually in seconds or minutes when placed on the tongue but there are still some changes due to chocking. Oral fast dissolving films is another way to solve this issue, as oral strips have been novel for the past few years and are well accepted by customers for distribution. Nowadays, breath strips, supplements and a variety of personal care items are commonly used by consumers. This review consists of updates on methods, ingredients and different technology used in fast dissolving film.

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“…These dosage forms dissolve (or disintegrate) rapidly in the mouth (within seconds), releasing the drug as a solution or suspension [6]. Fast-dissolving films can be produced with different techniques such as melt extrusion [7], solid dispersion extrusion [8], solventcasting [9], and electrospinning [10]. Due to its simplicity, low processing cost, and straightforwardness, solvent casting is the most preferred and common method for film fabrication [11].…”

Section: Introductionmentioning

confidence: 99%

A comparison between solvent casting and electrospinning methods for the fabrication of HPMC fast-dissolving films: investigation of the physicochemical, mechanical and drug release characteristics

Mortazavi,

kiani,

Zarei Chamgordani

et al. 2024

Phys. Scr.

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The fast-dissolving film is an innovative dosage form that rapidly delivers the loaded drug upon contact with saliva. Many studies have been conducted on the fabrication of fast-dissolving films using hydroxy propyl methyl cellulose (HPMC) as a common film-forming agent with solvent-casting method or sometimes with electrospinning. However, there is no comparison of these two methods on the physicochemical, mechanical, and drug-release behavior of HPMC films. This paper aims to compare bisoprolol-containing fast-dissolving films composed of HPMC and polyethylene glycol (PEG) as plasticizer constructed by solvent-casting and electrospinning methods.  Given the formulation parameters (e.g., plasticizer and polymer concentrations) and process parameters (e.g., tip-to-needle distance, voltage, and feed rate), various solvent-casting films and nanofiber mats were prepared. Films were characterized in terms of disintegration time, folding endurance, thermal behavior (using DSC), crystallin structure (using XRD), drug content, and drug release. The size and morphology of nanofibers were also evaluated by SEM.Solvent-casting film composed of 6% w/v HPMC and 6% v/v PEG400, as well as nanofiber mat composed of 13% w/v HPMC and 3% w/v PEG2000 were successfully constructed. DSC and XRD analysis revealed that the crystalline structure of bisoprolol converted into the amorphous structure in the polymeric films. Nanofibers were smooth and free of beads with a mean size of 0.66± 0.19 µm. In terms of flexibility, the nanofiber mats outperformed the solvent-casting films. The disintegration time of the nanofiber mat was less than that of the solvent-casting film (3 seconds versus 30 seconds). Besides, nanofibers indicated faster release. The superior performance of nanofiber mats can be attributed to their nanostructure.The results showed that the characteristics of the fast-dissolving films fabricated of HPMC, including disintegration time, release rate, and flexibility could be improved through the electrospinning process. 

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Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method

Cited by 17 publications

References 0 publications

Amorphous solid dispersion of ledipasvir and sofosbuvir for enhancement of oral bioavailability

Amorphous solid dispersion of ledipasvir and sofosbuvir for enhancement of oral bioavailability

Fast Dissolving Films: Brief review on preparation methods, ingredients and technology used

A comparison between solvent casting and electrospinning methods for the fabrication of HPMC fast-dissolving films: investigation of the physicochemical, mechanical and drug release characteristics

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