Design and Evaluation of Miconazole Nitrate loaded Nanostructured Lipid Carriers (NLC) for improving the Antifungal therapy

Sanap, Gajanan

doi:10.7324/japs.2013.30109

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…The NLC combination consists of a long and short chain of liquid and solid lipid, with varying lipid content from 5 to 40%. Surfactants stabilize NLC formulations in aqueous mediums at 0.5 to 5% w/w concentrations [26] . NLC is a blend of chemical substances with a melting point over 40°C, biodegradable in vivo, and a GRAS rating.…”

Section: Composition Of Nlcsmentioning

confidence: 99%

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

et al. 2024

IJFMR

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The normal human skin is exposed to different types of infection like wrinkles, pigmentation, acne, pimples in which pigmentation is most common in women over 30-40 years. The field of nanotechnology is currently intensely exploited for drug delivery technology for passive and active targeting via various routes of administration, such things can be effectively treated by incorporating the drug, loaded in a Nanostructured lipid carrier (NLC). NLCs have shown potential in delivering poorly soluble active components and in depigmenting. NLC springs up as the second generation of lipid nanoparticles to overcome the shortcomings of first generation through the topical route. NLC in topical administration provides some added advantages like increasing skin hydration and modified release profile and increase in skin penetration leading to avoidance of systemic absorption. NLCs are composed of biocompatible lipids, surfactants, and cosurfactants which help enhance drug loading capacity and stabilize the formulation. NLC's remarkable physicochemical and subsequently biocompatible qualities have created an ongoing need for the development of beneficial and safe drug delivery methods. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale-up, non-toxicity, improved drug loading, and stability Their ingredients have a special impact on the end product's physicochemical characteristics and efficacy. The present review aims to focus on the recent advancement in the preparation, characterization, and applications of NLC in treating hyperpigmentation.

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Section: Composition Of Nlcsmentioning

confidence: 99%

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

et al. 2024

IJFMR

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Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review

Baveloni

Riccio

Filippo

et al. 2021

CMC

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: Administration of substances through the skin represents a promising alternative, in relation to others drug administration routes, due to its large body surface area, in order to offer ideal and multiple sites for drug administration. In addition, the administration of drugs through the skin avoids first-pass metabolism, allowing an increase in the bioavailability of drugs, as well as reducing their side effects. However, the stratum corneum (SC) comprises the main barrier of protection against external agents, mainly due to its structure, composition and physicochemical properties, becoming the main limitation for the administration of substances through the skin. In view of the above, pharmaceutical technology has allowed the development of multiple drug delivery systems (DDS), which include liquid crystals (LC), cubosomes, liposomes, polymeric nanoparticles (PNP), nanoemulsions (NE), as well as cyclodextrins (CD) and dendrimers (DND). It appears that the DDS circumvents the problems of drug absorption through the SC layer of the skin, ensuring the release of the drug, as well as optimizing the therapeutic effect local. This review aims to highlight the DDS that include LC, cubosomes, lipid systems, PNP, as well as CD and DND, to optimize topical skin therapies.

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Formulation and evaluation of topical gel containing nanostructured lipid carriers dispersion of an antifungal drug

Gujjar¹,

Blr²,

Karki³

2019

actapharm

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Fungal infection are the common dermatological diseases. Drug delivery systems for topical use have shown significant advantages in targeting the drug to the action site in the body and also reduces the systemic side effects.In the present study an attempt was made to prepare econazole nitrate loaded nanostructured lipid carrier (NLC). Different formulations were prepared by hot homogenization technique using solid lipid and liquid lipid (GMS, GMO) and surfactants (Poloxamer 188, Poloxamer 407). Formulations were characterized for entrapment efficiency, viscosity, spreadability, pH and in vitro drug release.Entrapment efficiency of formulation F1-F8 was found to be 65.81-74.63%. The drug release of NLC gel followed zero order kinetics. NLC gel were stable at 40 ± 2ֹ°C and 75 ± 5% RH. Thus, the prepared NLC gel proved to be a potential candidate as a topical nanoparticulate sustained drug delivery system for econazole nitrate.

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Design and Evaluation of Miconazole Nitrate loaded Nanostructured Lipid Carriers (NLC) for improving the Antifungal therapy

Cited by 3 publications

References 16 publications

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

Nanostructured Lipid Carrier for Hyperpigmentation Treatment - a Dermal Prospective

Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review

Formulation and evaluation of topical gel containing nanostructured lipid carriers dispersion of an antifungal drug

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