Design and evaluation of two multi-pinhole collimators for brain SPECT

Chen, Ling; Tsui, B.M.W.; Mok, Greta S. P.

doi:10.1007/s12149-017-1195-y

Cited by 30 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cone-beam and fanbeam collimators were used to make better usage of the detector area than parallel-hole collimators when imaging a structure such as the head which is of smaller area than the detector, thereby improving the sensitivity / spatial resolution trade-off for imaging [20,21]. More recently, studies have shown that customized multi-pinhole collimators may further enhance the performance of the existing clinical generalpurpose SPECT systems for brain imaging [22][23][24][25][26].…”

mentioning

confidence: 99%

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Zeraatkar

Kalluri

Auer

et al. 2020

IEEE Trans. Med. Imaging

View full text Add to dashboard Cite

We designed a dedicated multi-detector multipinhole brain SPECT scanner to generate images of higher quality compared to general-purpose systems. The system, AdaptiSPECT-C, is intended to adapt its sensitivity-resolution trade-off by varying its aperture configurations allowing both high-sensitivity dynamic and high-spatial-resolution static imaging. The current system design consists of 23 detector heads arranged in a truncated spherical geometry. In this work, we investigated the axial and angular sampling capability of the current stationary system design. Two data acquisition schemes using limited rotation of the gantry and two others using axial translation of the imaging bed were also evaluated concerning their impact on image quality through improved sampling. Increasing both angular and axial sampling in the current prototype system resulted in quantitative improvements in image quality metrics and qualitative appearance of the images as determined in studies with specifically selected phantoms. Visual improvements for the brain phantoms with clinical distributions were less pronounced but presented quantitative improvements in the fidelity (normalized root-mean-square error (NRMSE)) and striatal specific binding ratio (SBR) for a dopamine transporter (DAT) distribution, and in NRMSE and activity recovery for a brain perfusion distribution. More pronounced improvements with increased sampling were seen in contrast recovery coefficient, bias, and coefficient of variation for a lesion in the brain perfusion distribution. The negligible impact of the most cranial ring of detectors on axial sampling, but its significant impact on sensitivity and angular sampling in the cranial portion of the imaging volume-of-interest were also determined. Index Terms-AdaptiSPECT-C, angular and axial sampling, SPECT, pinhole, multi-pinhole. I. INTRODUCTION B RAIN SPECT imaging has been of interest for many clinical applications in neuroimaging including Alzheimer's, Parkinson's, and Huntington's diseases,

show abstract

mentioning

confidence: 99%

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Zeraatkar

Kalluri

Auer

et al. 2020

IEEE Trans. Med. Imaging

View full text Add to dashboard Cite

show abstract

“…Resolution and sensitivity are two main performance factors in collimator designing [19]. The spatial resolution is often measured as: (1) the minimum distinguishable distance of two line sources or (2) the Full Width at Half Maximum (FWHM) from the Point Spread Function (PSF) [20][21][22]. Meanwhile, geometry of a collimator determines spatial resolution of a SPECT system [14,7,23,24].…”

Section: Classification Of the Collimatorsmentioning

confidence: 99%

“…Space limitation, spatial resolution and sensitivity are determinant in collimator selection for a particular imaging task [14,11]. An appropriate collimator needs to be selected for a specific imaging application, for instance a fan or cone beam collimator for brain imaging, a pin-hole collimator for thyroid, and parallel-hole collimator as generally used in SPECT and planar imaging [7,20,26].…”

Section: Classification Of the Collimatorsmentioning

confidence: 99%

“…The pin-hole collimation has been introduced to compensate the low photon detection efficiency of parallel-hole systems and to improve the image contrast [11,17]. The collimator consists of a single hole drilled into a lead sheet [6,20]. A pin-hole with knife edge geometry is the most popular pin-hole opening design (Figure 3) [14].…”

Section: Pin-hole Collimatorsmentioning

confidence: 99%

“…In comparison with a parallel-hole collimator, a pinhole collimator has a smaller Field of View (FOV) and so preferred in focal uptake imaging [7,20]. Due to the small FOV, pin-hole collimation has insufficient axially coverage of an entire animal for small animal imaging and also suffers from the low detection efficiency [13,14,45].…”

Section: Pin-hole Collimatorsmentioning

confidence: 99%

See 2 more Smart Citations

Review on Recent Developments in Collimators of Single Photon Emission Computed Tomography Imaging

Darkhor

Islamian

2020

fbt

View full text Add to dashboard Cite

In Single Photon Emission Computed Tomography (SPECT), collimator selection, optimization, and also geometric calibration have a major impact on the acquired image quality and also on an accurate detectability and diagnosis. The collimator optimization phenomena consider some parameters such as field of view, resolution, sensitivity, resolution at depth, septal thickness and penetration for a specific application task. While the parallel hole collimator is usually used in SPECT and planar imaging but due to the limited solid angle covered by the collimator, the system sensitivity and resolution were highly reduced. Meanwhile, other types of collimators such as pin-hole, multi-pin-hole, slant and slit-slat collimators were introduced with a trade-off between sensitivity and resolution. This article reviews improvements on collimators also by considering the geometry and geometric calibration methods for improving the image quality in single photon emission computed tomography.

show abstract

SPECT and SPECT/CT

2021

View full text Add to dashboard Cite

Design and evaluation of two multi-pinhole collimators for brain SPECT

Abstract: The two collimator designs provide superior image quality as compared to the conventional LEHR, and shows potential to improve current brain SPECT imaging based on a conventional SPECT scanner.

Cited by 30 publications

References 34 publications

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Investigation of Axial and Angular Sampling in Multi-Detector Pinhole-SPECT Brain Imaging

Review on Recent Developments in Collimators of Single Photon Emission Computed Tomography Imaging

SPECT and SPECT/CT

Contact Info

Product

Resources

About