Design and microfabrication strategies for thin-film, flexible optical neural implant

Kampasi, Komal; Alameda, Jennifer B.; Sahota, Sarah; Hernandez, J.E.; Patra, S.; Haque, Razi

doi:10.1109/embc44109.2020.9175440

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Today, PI is already a very mature material and widely available in various forms (Liang et al, 1992 ; Rousche et al, 2001 ; Hassler et al, 2011 ; Bakonyi et al, 2013 ; Kim et al, 2013 ). PI has a great potential for a variety of applications in neural implants (Mian et al, 2005 ; Rubehn and Stieglitz, 2010 ; Viventi et al, 2011 ; Schaubroeck et al, 2017 ; Kampasi et al, 2020 ), such as multi-level interconnects, multi-chip module packaging, and flexible circuitry (Frazier, 1995 ). Compared with PA, PI provides better high-temperature stability (up to 400°C), higher glass transition temperature (Kim and Meng, 2015 ), better dielectric properties (Frazier, 1995 ), and lower moisture absorption.…”

Section: Packaging and Substrate Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Packaging and Substrate Materialsmentioning

confidence: 99%

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…Recently, flexible polymer-based neural probes have been reported [ 37 , 38 ]. Advantages of the flexible polymer-based neural probes over the rigid silicon-based neural probes include low elastic modulus, good biocompatibility, and low mechanical mismatch.…”

Section: Introductionmentioning

confidence: 99%

Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications

Guo

Wang

et al. 2021

IJMS

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With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being conducted at a desirably high temporal resolution. Here, a flexible polyimide-based neural probe with polyethylene glycol (PEG) packaged optical fiber and Pt-Black/PEDOT-GO (graphene oxide doped poly(3,4-ethylene-dioxythiophene)) modified microelectrodes was developed to reduce the stimulation artifacts that are induced by photoelectrochemical (PEC) and photovoltaic (PV) effects. The advantages of this design include quick and accurate implantation and high-resolution recording capacities. Firstly, electrochemical performance of the modified microelectrodes is significantly improved due to the large specific surface area of the GO layer. Secondly, good mechanical and electrochemical stability of the modified microelectrodes is obtained by using Pt-Black as bonding layer. Lastly, bench noise recordings revealed that PEC noise amplitude of the modified neural probes could be reduced to less than 50 µV and no PV noise was detected when compared to silicon-based neural probes. The results indicate that this device is a promising optogenetic tool for studying local neural circuits.

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POEMS (Polymeric Opto-Electro-Mechanical Systems) for advanced neural interfaces

et al. 2021

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Design and microfabrication strategies for thin-film, flexible optical neural implant

Cited by 4 publications

References 26 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications

POEMS (Polymeric Opto-Electro-Mechanical Systems) for advanced neural interfaces

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