Design and modelling of photonic sensor for cancer cell detection

A new optimized bowl-shaped mono-core surface plasmon resonance based cancer sensor is proposed for the rapid detection of different types of cancer affected cell. By considering the refractive index of each individual cancer contaminated cell with respect to their normal cell, some major optical parameters variation are observed. Moreover, the cancerous cell concentration is considered at 80% in liquid form and the detection method is finite element method with 2 100 390 mesh elements. The variation of spectrum shift is obtained by plasmonic band gap between the silica and cancer cell part which is separated by a thin (35 nm) titanium film coating. The proposed sensor depicts a high birefringence of 0.04 with a maximum coupling length of 66 μm. However, the proposed structure provides an optimum wavelength sensitivity level between about 10 000 nm/RIU and 17 500 with a resolution of the sensor between 1.5 × 10 −2 and 9.33 × 10 −3 RIU. Also, the transmittance variance of the cancerous cell ranges from almost 3300 to 6100 dB/RIU and the amplitude sensitivity ranges nearly between −340 and −420 RIU −1 for different cancer cells in major polarization mode with the maximum detection limit of 0.025. Besides, the overall sensitivity performance is measured with respect to their normal cells which can be better than any other prior structures that have already proposed.

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“…1(b). The effective RI of the proposed model is derived from Sellmeier's RI equation for fused silica material [20] can be defined by,…”

Section: Theoretical Analysismentioning

confidence: 99%

Surface Plasmon Resonance Based Titanium Coated Biosensor for Cancer Cell Detection

et al. 2019

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“…Typically, PC is having PBG, which is entirely broken by introducing either line defect or point defect. By breaking the defects, PC based optical devices, such as filter [14,15], directional coupler [16], demultiplexer [17,18], triplexer [19,20], power splitter [21,22], logic gates [23], switches [24,25], electro-optical modulators [26,27], add-drop filter [28,29], and sensors [30][31][32][33][34][35][36][37][38][39][40][41], were reported.…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, PC/PCRR based sensors were reported for bio sensing applications [30,31], salinity sensor for different temperatures [32], chemical sensor [33], force/strain sensor applications [34,35], pressure sensor [36], biosensor to detect the glucose concentration in urine [5,37,38], aqueous environment [39], breast cancer [40], cancer cell detection [41], pregnancy test, etc. In this paper, a photonic crystal based biosensor is designed, and sensing characteristics such as the Q factor, resonant wavelength, and normalized output power are estimated for albumin, bilirubin, urea, and glucose in urine and also glucose concentration in blood.…”

Section: Introductionmentioning

confidence: 99%

Photonic crystal based biosensor for the detection of glucose concentration in urine

Robinson¹,

Dhanlaksmi²

2016

Photonic Sens

108

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Photonic sensing technology is a new and accurate measurement technology for bio-sensing applications. In this paper, a two-dimensional photonic crystal ring resonator based sensor is proposed and designed to detect the glucose concentration in urine over the range of 0 gm/dl-15 gm/dl. The proposed sensor is consisted of two inverted "L" waveguides and a ring resonator. If the glucose concentration in urine is varied, the refractive index of the urine is varied, which in turn the output response of sensor will be varied. By having the aforementioned principle, the glucose concentration in urine, glucose concentration in blood, albumin, urea, and bilirubin concentration in urine are predicted. The size of the proposed sensor is about 11.4 m×11.4 m, and the sensor can predict the result very accurately without any delay, hence, this attempt could be implemented for medical applications.

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“…Some unique novel properties of PCFs have drawn the attraction of researchers for its more flexibility than conventional optical fibers. Development of regular or irregular PCF structure helps researchers to achieve more efficiency as well as use it in multipurpose like gas sensing [2][3][4][5][6], chemical sensing [7], bio sensing [8], cancer cell detection [9], medical science [10], and temperature sensing [11][12]. Like different structural shape, geometrical parameters of fiber are also responsible to vary guiding properties [13].…”

Section: Introductionmentioning

confidence: 99%

Design of Simple Structure Gas Sensor Based on Hybrid Photonic Crystal Fiber

Asaduzzaman¹,

Ahmed²,

Bhuiyan³

2016

CSJ

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Abstract.A hybrid structure photonic crystal fiber gas sensor is presented in this paper to detect toxic and colorless gases. The guiding properties of proposed structure have been numerically investigated using finite element method (FEM). From the numerical results sensitivity of the proposed structure is enhanced to 15.67%. The Confinement loss or Leakage loss decreased to 1.12×10-7 by acquainting an octagonal ring of air holes in the outer cladding. The proposed H-PCF can be used in a wider range of wavelength from 0.8µm to 2 µm. The proposed structure has significantly lower confinement losses, higher sensitivity and is more flexible for its simplicity compared with early proposed PCFs.Keywords: Hybrid Photonic Crystal Fiber (H-PCF), Evanescent Field, Gas Sensor, Sensitivity, Finite Element Method and Confinement Loss. Hibrit Kaplamaları Photonıc Kristal Fibere Dayalı Basit Yapılı Gaz Sensörü TasarımıÖzet. Bir melez yapılı fotonik kristal fiber gaz sensörü, toksik ve renksiz gazları algılamak için, bu çalışmada sunulmuştur. Önerilen yapının yol gösterici özellikleri sayısal sonlu elemanlar metodu (FEM) kullanılarak incelenmiştir. Sayısal sonuçlardan önerilen yapı duyarlılığı %15.67'e yükseltilmiştir. Hapsetme kaybı ya da kaçak kaybı, dış cephe hava deliklerinin sekizgen halka yapısı ile 1.12 × 10 -7 değerine düşmüştür. Önerilen H-PCF, 0.8μm ile 2 um dalga boyu aralığında kullanılabilir. Önerilen yapı, daha düşük hapsi kayıpları, yüksek duyarlılık sahibidir ve önceden önerilen PCFs ile karşılaştırıldığında sadeliği için daha esnektir.

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Design and modelling of photonic sensor for cancer cell detection

Cited by 49 publications

References 5 publications

Surface Plasmon Resonance Based Titanium Coated Biosensor for Cancer Cell Detection

Surface Plasmon Resonance Based Titanium Coated Biosensor for Cancer Cell Detection

Photonic crystal based biosensor for the detection of glucose concentration in urine

Design of Simple Structure Gas Sensor Based on Hybrid Photonic Crystal Fiber

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