Design and synthesis of a novel lanthanide fluorescent probe (TbIII-dtpa-bis(2,6-diaminopurine)) and its application to the detection of uric acid in urine sample

Yang, Fan; Yu, Zhiyue; Ren, Pengwei; Liu, Guanhong; Song, Youtao; Wang, Jun

doi:10.1016/j.saa.2018.06.011

Cited by 28 publications

(11 citation statements)

References 44 publications

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“…As the most optimal research object, urine can be noninvasively collected and carries important physical and chemical information related to many metabolic diseases, such as diabetes, gouty arthritis, and renal disease diacrisis. [ 16 , 17 ] Many methods have been established to measure the UA level in urine, including absorption spectrophotometry, [ 18 ] fluorescence biosensors, [ 17 , 19 ] electrochemical biosensors, [ 20 , 21 ] high‐performance liquid chromatography‐ultraviolet (HPLC‐UV), [ 22 ] and HPLC‐mass spectrometry, [ 23 ] all of which can be employed to monitor UA in urine with the merits of high sensitivity and excellent specificity to facilitate the diagnosis of hyperuricemia. Noticeably, the use of harmful reagents as mobile phase or solvent poses a threat to the environment and human health, which deviates from the concept of green development.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Zhang

Chai

et al. 2022

Advanced Science

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Characterized by an excessively increased uric acid (UA) level in serum, hyperuricemia induces gout and also poses a great threat to renal and cardiovascular systems. It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self-built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar-level, while simultaneously excluding fluorescein (Fl) from the GC5A•Fl complex in the "switch-on" mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital-centered to individual-centered testing, visual detection of UA is studied through a smartphone equipped with a color-scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family-centered healthcare style. A high-throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.

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Section: Introductionmentioning

confidence: 99%

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Zhang

Chai

et al. 2022

Advanced Science

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“…Uric acid (UA), chemically designated as 2, 6, 8-tryhydroxypurine, is a major product of the catabolism of purine nucleosides, adenosine and guanosine. The normal concentration of uric acid in human urine varies between 1.4−4.46 mM and values higher than 4.46 mM are used for gout disease diagnosis (Azmi et al 2015;Liu et al 2019;Yang et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Non-invasive sensors of UA in human urine have been recently developed (Bai et al 2017;Yang et al 2018), and various techniques, such as liquid chromatography (Li et al 2015), capillary electrophoresis (Pormsila et al 2009), and uorescence spectroscopy (Azmi et al 2018) have been used for UA detection. However, while these techniques offer high sensitivity and precision, they also have some limitations such as high cost, and the requirement of highly trained personnel.…”

Section: Introductionmentioning

confidence: 99%

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

et al. 2021

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We report on the development of an electrochemical sensor platform based on modi ed cotton bers for the non-enzymatic detection of uric acid (UA), an important biomarker for gout disease. To create the exible electrode, a cotton thread was coated with carbon ink followed by the electrodeposition of AuNPs.Then, differential pulse voltammetry (DPV) was used to evaluate the sensor performances, and a linear detection range between 10 µM and 5.0 mM of uric acid was obtained. The sensor has a low detection limit of 0.12 µM, which is optimal for use in the patients suffering from gout disease which commonly experience concentrations of uric acid in urine higher than 4.46 mM. Furthermore, we found that the detection sensitivity of the platform was not affected by the presence of other physiological compounds present in human urine. The described platform has the potential for integration in a diaper hence enabling rapid detection and screening for gout disease.

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“…A number of methods have been established for the determination of UA, such as electrochemical methods [5], chromatography [6], capillary electrophoresis [7], fluorescence methods [8], paper based technique [9] colorimetry [10], and molecular spectroscopy [11]. Since the electrochemical methods and chromatography are time-consuming, expensive equipment, and inconvenient and easily interfered, these methods were often limited in use [12,13].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Detection of Uric Acid with High Sensitivity Using Cu2O@Ag Nanocomposites

Wang

Tang

et al. 2020

Chemistry Africa

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In this paper, we built the Cu 2 O@Ag nanocomposites-catalyzed 3,3′,5,5′-tetramethylbenzidine (TMB)-H 2 O 2 system for sensitive, rapid, and low-cost colorimetric sensing of uric acid (UA). Firstly, Ag nanotriangles were synthesized by dynamic method, and then Cu 2 O was encapsulated on the nanoflakes to synthesize Cu 2 O@Ag nanocomposites. Characterization of the structure and morphology of nanocomposites material were characterized by transmission electron microscopy, X-ray energy-dispersive spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Cu 2 O@Ag nanocomposites could catalyze the oxidation of TMB by H 2 O 2 (which is produced by enzymatic oxidation of UA), and the color changes from colorless to blue can be observed directly with the naked eyes or can be detected by UV-Vis spectrophotometer. The colorimetric sensor provided a linear absorbance response in the 0.5-100 μM UA concentration range with a 0.4 μM detection limit (S/N = 3). The recovery of UA in human serum by the proposed sensor is over 95.7%. Thus, these results imply that the UA sensor provides an effective tool in fast clinical analysis of gout without the need for expensive and advanced equipment.

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Design and synthesis of a novel lanthanide fluorescent probe (TbIII-dtpa-bis(2,6-diaminopurine)) and its application to the detection of uric acid in urine sample

Cited by 28 publications

References 44 publications

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Colorimetric Detection of Uric Acid with High Sensitivity Using Cu2O@Ag Nanocomposites

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