Design and synthesis of novel benzimidazole-iminosugars linked a substituted phenyl group and their inhibitory activities against β-glucosidase

Binding interactions of hydrophobically-modified flavonols with β-glucosidase: fluorescence spectroscopy and molecular modelling study

“…It has been noticed that the peripheral phenyl rings of an inhibitor molecule could be faced towards the solvent-exposed region of an enzyme, which played an essential effect in anti-β-glucosidase activity. 34 Our molecular docking demonstrates that, in terms of the binding affinity, the studied flavonols are among strong β-glucosidase binders with the comparable and higher affinity than available inhibitors Imd2 and Cas2 (Table 5).…”

“…30 Therefore, many glycosidase inhibitors have been isolated from natural sources or synthesized to optimize their inhibitory potency. 31–37 Inhibition of the catalytic activity of glycosidase enzymes has great potential in developing highly potent and specific drugs against such diseases as diabetes, cancer, and viral infections. 37,38…”

Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies

“…Nano-curcumin could give anticancer effects via targeting the β-glucosidase in the treatment of cancer. 51 …”

“…Nano-curcumin could give anticancer effects via targeting the b-glucosidase in the treatment of cancer. 51 The inhibition activity is closely related to the particle size. Greater the particle size, lower will be the activity.…”

Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance

“…Iminosugars, containing an endocycling nitrogen atom that effectively mimics carbohydrates by facilitating the reversible and competitive inhibition of their processing enzymes, have generated much attention in recent years as targets in the treatment of a wide range of illnesses (e.g., diabetes, cancer, tuberculosis, and lysosomal storage disorders, etc.) [ 1 , 2 , 3 , 4 , 5 , 6 ]. Given the enormous range of biochemical events in which carbohydrate processing enzymes are implicated, iminosugars have enormous potential to be developed as inhibitors of glycosidases (glycoside hydrolases), glycosyltransferases (glycoside synthases), metalloproteinases, and nucleoside-processing enzymes [ 7 , 8 , 9 , 10 , 11 ].…”