Design, characterization and evaluation of Eudragit microspheres containing glipizide

Joshi, Atrey S.; Patil, C. C.; Shiralashetti, S. S.; Kalyane, Navanath V.

doi:10.1016/j.dit.2013.06.009

Cited by 22 publications

(20 citation statements)

References 8 publications

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“…The surface of the drug-loaded Eudragit RS100 nanoparticles manifested the presence of drug particles. 27 DSC has shown to be an important tool to quickly obtain information about possible interactions between the active scanning electron microscope photography of drug-loaded Eudragit RS100 nanoparticles (E1) and the excipients, according to the appearance, shift, or disappearance of endothermic or exothermic peaks. 28 DSC gives an insight into melting and recrystallization behaviors of polymeric nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Yenilmez

2017

tjps

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ÖZAmaç: Bu çalışmanın amacı, Desloratadin-Eudragit ® RS100 nanopartiküllerini formüle etmek ve hazırlanan nanopartiküllerin özelliklerini araştırmaktır. Gereç ve Yöntemler: Nanopartiküller püskürterek kurutma yöntemi ile hazırlanmış ve miktar tayini yüksek basınçlı sıvı kromatografisi (YBSK) yöntemi ile yapılmıştır. Bulgular: Desloratadin (DL) başarıyla polimere yüklenmiş ve geliştirilen YBSK yönteminin doğrusal, tekrarlanabilir, hassas, doğru, spesifik ve selektif olduğu bulunmuştur. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatının hazırlanmasında başarı ile kullanılmıştır. Nanopartiküllerin karakterizasyonu partikül boyutu, zeta potansiyel, morfoloji, polidispersite indeksi, katı hal karakterizasyonları ve etkin madde salımı dahil olmak üzere yapılmıştır. DL yüklü nanopartiküllerin in vitro salım çalışmaları, simüle edilmiş barsak vasatında (pH 7.4) incelenmiştir. Nanopartikül formülasyonlarından DL'nin in vitro salımı, Korsemeyer-Peppas modeline uymaktadır. Sonuç: DL miktar tayini için YBSK yöntemi geliştirilmiştir. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatına başarıyla uygulanmıştır. Ayrıca, tüm nanopartiküllerin ve etkin maddenin salım çalışmaları karşılaştırmalı olarak incelenmiştir. Bu nedenle, DL yüklü nanopartiküllerin etkin madde için umut verici bir ilaç taşıyıcı sistem olduğu sonucuna varılabilir. Anahtar kelimeler: Desloratadin, Eudragit ® RS100, YBSK, nanopartikül Objectives:The objective of the present study was to formulate Desloratadine-Eudragit ® RS100 nanoparticles and investigate the characteristics of the prepared nanoparticles. Materials and Methods: The nanoparticles were prepared by spray drying method and the quantification of desloratadine (DL) was carried out with a high performance liquid chromatography (HPLC) method. Results: DL was successfully loaded to polymer and the developed HPLC method was found to be linear, reproducible, precise, accurate, specific and selective. Characterization of the nanoparticles including entrapment efficiency, particle size, zeta potential, morphology, polidispersity index, solid state characterizations and drug release was performed. In vitro release studies of DL loaded nanoparticles were also examined in the simulated intestinal fluid (pH 7.4). In vitro release of DL from nanoparticle formulations followed Korsemeyer-Peppas model. Conclusion: A validated HPLC method was developed for the determination of DL. Proposed spray drying method can be successfully applicable to the nanoparticle preparation containing DL. In addition, the release studies of all nanoparticles and active substance have been studied comparatively. Hence, it could be concluded that DL loaded nanoparticles seem to be a promising drug delivery system for the active agent.

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Section: Resultsmentioning

confidence: 99%

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Yenilmez

2017

tjps

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“…4 Sumatriptan succinate loaded Eudragit E microparticles were prepared using w/o/w emulsion solvent evaporation method. 16,17 Drug: polymer ratio, PVA% and type of the external force (stirrer or homogenizer) were important factors to obtain microparticles with higher drug loading percentage.…”

Section: Fig 3: Drug Release Profiles Of A) Microparticles Prepared mentioning

confidence: 99%

“…16,17 w/o/w emulsion solvent evaporation: For w/o/w emulsion, constant amount of sumatriptan succinate was dissolved in deionized water by vortexing (VELP, Spain) and bath sonicator (TECNO-GAS, Italy). Eudragit E was also dissolved in dichloromethane and then aqueous solution of drug was added to dichloromethane solution under probe sonicator (Hielscher, Germany) to prepare a w/o emulsion.…”

Section: Preparationmentioning

confidence: 99%

Untitled

2017

IJPSR

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Sumatriptan succinate, a selective 5-hydroxytryptamine-1 receptor agonist, is an antimigraine drug with bitter-taste. The present study was performed to prepare and evaluate eudragit-E microparticles containing sumatriptan and formulate fast disintegrating tablets of drug microparticles to increase patient-compliance and improve the efficacy of drug. Microparticles were prepared by solvent-evaporation method using waterdichloromethane/PVA and water-dichloromethane/liquid paraffin systems. The effect of different variables (polymer:drug ratio, PVA concentration and solvents combination ratios) on particle size and encapsulation efficiency of the microparticles was investigated. The final microparticles were evaluated for particle size, loading percent, taste-masking, thermal analysis and in-vitro release profile. The drug loading were higher in w/o/o emulsion than w/o/w. Mean particle size was not statistically different for different formulations. Sumatriptan release rate from eudragit-E microparticles was very fast in HCl 0.1 N medium and release profile was acceptable for fast disintegrating tablets. The prepared tablets were evaluated for in-vitro disintegration time, weight variation, hardness, friability and in-vitro drug release. The optimized formulation (F6) (provided a pleasant taste and mouth-feel) disintegrated within 20 seconds and released more than 70% of drug within 15 minutes. Tablets formulated by drug loaded eudragit-E microparticles could be a promising formulation for tastemasking and decreasing failure in triptans therapy.

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“…20, 21 Eudragit RS 100 and RL 100 are taken due to their biocompatibility, good stability, easy fabrication and insolubility in gastric juice. [22][23][24][25] In contrary to conventional dosage forms like tablets and capsules, formulations which are present in the market with better effectiveness also have higher side effects on gastrointestinal system 26 and cardiovascular system 27 on administration of more than 400mg dose. The use of microsphere for drug delivery is not limited to any specific illness, rather they can be widely applied in many situations where continuous or controlled drug administration is essential.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere.

Ruhidas¹,

Naskar²,

Banerjee³

et al. 2016

IJPER

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Aims:The aim of present study was to evaluate Gum Katira obtained from the plant Cochlospermum religiosum (Family Cochlospermaceae) as a matrix forming pharmaceutical excipient for a novel drug delivery system. Materials and Methods: Gum Katira was used for the drug release retarding material in microsphere formulation using Etodolac as a model drug. Etodolac was found to be compatible with the matrix material Gum Katira by conducting the various physiochemical and instrumental analysis. Result: Etodolac loaded Gum Katira microsphere (ELGKM) was compared with Etodolac loaded sodium alginate microsphere (ELSAM) and blank microsphere (without gum matrix), which subsequently revealed that the drug release rate of ELGKM was better for sustained and controlled release. Conclusion: In our experiment, it was found that the drug release mechanism best fitted in Korsmeyers Peppas model on comparing the correlation coefficient values of different mathematical models. The result of this study indicates that ELGKM (1% w/v Gum Katira) would be desired formulations in delivering the drug with controlled and sustained release pattern.

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Design, characterization and evaluation of Eudragit microspheres containing glipizide

Cited by 22 publications

References 8 publications

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Desloratadine-Eudragit<sup>®</sup> RS100 Nanoparticles: Formulation and Characterization

Untitled

Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere.

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