Design, economic evaluation and optimization of enzymatic membrane reactors for antibiotics degradation in wastewaters

Abejón, Ricardo; Belleville, Marie‐Pierre; Sánchez-Marcano, José

doi:10.1016/j.seppur.2015.09.072

Cited by 32 publications

(14 citation statements)

References 65 publications

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“…Laccases immobilized by different methods have been used for antibiotic degradation, including enzymatic membrane reactors (Nguyen et al, 2014b ; Becker et al, 2016 ), granular activated carbon (Nguyen et al, 2016a ), silica beads (Rahmani et al, 2015 ), oriented immobilization (Shi et al, 2014 ), magnetic cross-linked enzyme aggregates (Kumar and Cabana, 2016 ; Yang et al, 2017 ), and cell surface display (Chen et al, 2016 ). In particular, enzymatic membrane reactors (gelatin-ceramic membranes grafted with commercial T. versicolor laccase) in tetracycline degradation have been evaluated in depth with respect to membrane preparation, efficiency, kinetics, and economics (de Cazes et al, 2014 , 2015 ; Abejón et al, 2015a , b ). Mathematical cost estimation indicates that the enzymatic process is still economically uncompetitive.…”

Section: Laccase Applications In Biodegradation Of Ppcpsmentioning

confidence: 99%

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

et al. 2017

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Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical properties, and expression to immobilization and applications. This review is not intended to be all-encompassing; instead, we highlighted some of the latest developments in basic and applied laccase research with an emphasis on laccase-mediated bioremediation of pharmaceuticals, especially antibiotics. Pharmaceuticals are a broad class of emerging organic contaminants that are recalcitrant and prevalent. The recent surge in the relevant literature justifies a short review on the topic. Since low laccase yields in natural and genetically modified hosts constitute a bottleneck to industrial-scale applications, we also accentuated a genus of laccase-producing white-rot fungi, Cerrena, and included a discussion with regards to regulation of laccase expression.

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Section: Laccase Applications In Biodegradation Of Ppcpsmentioning

confidence: 99%

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

et al. 2017

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“…In order to have a simplified outlook to the multi-objective optimization of the installation, Pareto graphs were prepared. Pareto optimal solutions are solutions that cannot be improved in one objective function without deteriorating the performance in at least another objective [33]. In this case, the epsilon constraint method was employed to obtain Pareto graphs that included the total membrane area compared to total air consumption or total heat requirements [34,35].…”

Section: Parameter Unit Valuementioning

confidence: 99%

Concentration of 1,3-dimethyl-2-imidazolidinone in Aqueous Solutions by Sweeping Gas Membrane Distillation: From Bench to Industrial Scale

et al. 2019

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Sweeping gas membrane distillation (SGMD) is a useful option for dehydration of aqueous solvent solutions. This study investigated the technical viability and competitiveness of the use of SGMD to concentrate aqueous solutions of 1,3-dimethyl-2-imidazolidinone (DMI), a dipolar aprotic solvent. The concentration from 30% to 50% of aqueous DMI solutions was attained in a bench installation with Liqui-Cel SuperPhobic® hollow-fiber membranes. The selected membranes resulted in low vapor flux (below 0.15 kg/h·m2) but were also effective for minimization of DMI losses through the membranes, since these losses were maintained below 1% of the evaporated water flux. This fact implied that more than 99.2% of the DMI fed to the system was recovered in the produced concentrated solution. The influence of temperature and flowrate of the feed and sweep gas streams was analyzed to develop simple empirical models that represented the vapor permeation and DMI losses through the hollow-fiber membranes. The proposed models were successfully applied to the scaling-up of the process with a preliminary multi-objective optimization of the process based on the simultaneous minimization of the total membrane area, the heat requirement and the air consumption. Maximal feed temperature and air flowrate (and the corresponding high operation costs) were optimal conditions, but the excessive membrane area required implied an uncompetitive alternative for direct industrial application.

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“…However, the use of laccases as a biocatalyst is associated with some limitations as it suffers from low sensitivity, the problem of denaturing agents, and the fact that they are non-reusable, hence not economically viable [18]. The aforementioned challenges for laccases need viable solutions and it is in this idea that some researchers have suggested immobilizing laccases onto carriers in order to play a role as protective agents and also offer the much-needed stability and improved efficiency [17,[19][20][21][22][23]. However, the process of immobilizing laccase enzymes onto carriers has also been reported to be accompanied by a significant loss of enzyme activity, which again has prompted scientists and researchers to embark on finding a solution [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Laccase Immobilized Fe3O4-Graphene Oxide Nanobiocatalyst Improves Stability and Immobilization Efficiency in the Green Preparation of Sulfa Drugs

et al. 2020

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This paper, reports on the novel and green synthesis procedure for sulfonamides that involved the immobilization of Trametes Versicolor laccase onto the Fe3O4–graphene nanocomposite via glutaraldehyde (GA) crosslinking (Lac/Fe3O4/GO). Various parameters, mainly, activation time, GA, and laccase concentration were investigated and optimized. The results showed that the optimal contact time was 4 h, GA concentration was 5% while laccase concentration was 5 mg·mL−1, at which a high enzyme activity recovery was achieved (86%). In terms of the stability of immobilized laccase to temperature and storage conditions, the performance of the nanobiocatalyst was found to significantly exceed that of free laccase. The results have indicated that nearly 70% of relative activity for immobilized laccase remained after the incubation period of 2 h at 55 °C, but only 48% of free laccase remained within the same time period. Moreover, the immobilized laccase retained 88% of its initial activity after storage for 20 days. In case of the free laccase, the activity retained within the same time period was 32%. In addition, the nanobiocatalyst possessed better recycling performance as evidenced from the observation that after eight cycles of repeated use, it retained 85% of its original activity.

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Design, economic evaluation and optimization of enzymatic membrane reactors for antibiotics degradation in wastewaters

Cited by 32 publications

References 65 publications

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

Concentration of 1,3-dimethyl-2-imidazolidinone in Aqueous Solutions by Sweeping Gas Membrane Distillation: From Bench to Industrial Scale

Laccase Immobilized Fe3O4-Graphene Oxide Nanobiocatalyst Improves Stability and Immobilization Efficiency in the Green Preparation of Sulfa Drugs

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