2017
DOI: 10.4103/kleuhsj.kleuhsj_131_17
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Design, formulation, and evaluation of in situ gelling ophthalmic drug delivery system comprising anionic and nonionic polymers

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Cited by 14 publications
(9 citation statements)
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“…The concentrations of polymers are crucial on the effects of residence time, viscosity, as well as the release of the drug within the gelling system [ 9 ]. HPMC and SA have been decided as the bioadhesive polymers to be used in the development of the formulation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The concentrations of polymers are crucial on the effects of residence time, viscosity, as well as the release of the drug within the gelling system [ 9 ]. HPMC and SA have been decided as the bioadhesive polymers to be used in the development of the formulation.…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, using an in situ gel with a prolonged contact time and a sustained drug release effect could improve the therapeutic efficacy as the inflammation is mainly found at the epidermis and upper dermis skin layer [ 8 ]. In situ gels are viscous liquids which have a unique characteristic of undergoing sol-to-gel transitions by the influence of various stimuli, namely pH, temperature, and electrolytes [ 9 ]. In this study, the focus of sol-gel transition was made on the temperature-dependent factors, where the conversion of sol-to-gel conversion was projected to the stimuli of skin temperature.…”
Section: Introductionmentioning
confidence: 99%
“…The spindle angular velocity was increased to 0.3, 0.5, 0.6, 1, 1.5, 2, 2.5, 3.4, 5, 6, 10, and the viscosity of the formulation was recorded. 26…”
Section: Viscosity Measurementmentioning
confidence: 99%
“…To cope with these drawbacks, in situ gel systems have emerged as one of the best novel drug delivery systems. It can enhance the bioavailability of ocular drugs by sustaining and controlling the release of drugs in the pre-corneal region [10,11]. In situ drug delivery systems consist of polymers that develop sol-to-gel phase transition due to changes such as temperature, pH or electrolyte composition of the eye environment [12,13].…”
Section: Introductionmentioning
confidence: 99%