The Box‐Behnken experimental design method was applied to study optimization of dry reforming of methane over a magnesia‐supported nickel catalyst (Ni/MgO). The catalyst was prepared by impregnation method and characterized using Brunauer‐Emmett‐Teller analysis, X‐ray diffraction, thermogravimetric analysis, and transmission electron microscopy. Response surface methodology (RSM) modified by the Box‐Cox method was applied to investigate the effect of different operating parameters on conversion and formation of the different components of the reaction system. The RSM‐generated predictive models verified by analysis of variance were used to simulate the responses of the operating variables. This study revealed that the reaction temperature has the most pronounced effect followed by the CO2/CH4 mole ratio while the gas hourly space velocity had a negligible impact.