Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

Ghane, Nazanin; Beigi, Mohammad‐Hossein; Labbaf, Sheyda; Nasr-Esfahani, Mohammad Hossein; Kiani, Amirkianoosh

doi:10.1039/d0tb01842b

Cited by 50 publications

(25 citation statements)

References 254 publications

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“…249 Essential parameters such as structural stability, the local microenvironment mimicry, and cell or biomolecule deliverability should be taken into consideration on designing an engineered scaffold for SCI repair. 250 Hydrogel is a promising type of scaffold for SCI regeneration. Physiologically, hydrogels exhibited the soft tissue properties and served as a temporary mimetic niche for cells, 215 and they also contained high levels of water and macromolecular components which could simulate the aqueous microenvironment of the ECM and local tissue.…”

Section: Application Of 2d Nanomaterials For Cns and Pns Injurymentioning

confidence: 99%

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Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration

Halim

Zhang

et al. 2021

ACS Biomater. Sci. Eng.

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The complexity of the nervous system structure and function, and its slow regeneration rate, makes it more difficult to treat compared to other tissues in the human body when an injury occurs. Moreover, the current therapeutic approaches including the use of autografts, allografts, and pharmacological agents have several drawbacks and can not fully restore nervous system injuries. Recently, nanotechnology and tissue engineering approaches have attracted many researchers to guide tissue regeneration in an effective manner. Owing to their remarkable physicochemical and biological properties, two-dimensional (2D) nanomaterials have been extensively studied in the tissue engineering and regenerative medicine field. The great conductivity of these materials makes them a promising candidate for the development of novel scaffolds for neural tissue engineering application. Moreover, the high loading capacity of 2D nanomaterials also has attracted many researchers to utilize them as a drug/gene delivery method to treat various devastating nervous system disorders. This review will first introduce the fundamental physicochemical properties of 2D nanomaterials used in biomedicine and the supporting biological properties of 2D nanomaterials for inducing neuroregeneration, including their biocompatibility on neural cells, the ability to promote the neural differentiation of stem cells, and their immunomodulatory properties which are beneficial for alleviating chronic inflammation at the site of the nervous system injury. It also discusses various types of 2D nanomaterials-based scaffolds for neural tissue engineering applications. Then, the latest progress on the use of 2D nanomaterials for nervous system disorder treatment is summarized. Finally, a discussion of the challenges and prospects of 2D nanomaterials-based applications in neural tissue engineering is provided.

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Section: Application Of 2d Nanomaterials For Cns and Pns Injurymentioning

confidence: 99%

“…Essential parameters such as structural stability, the local microenvironment mimicry, and cell or biomolecule deliverability should be taken into consideration on designing an engineered scaffold for SCI repair . Hydrogel is a promising type of scaffold for SCI regeneration.…”

Section: Application Of 2d Nanomaterials For Cns and Pns Injurymentioning

confidence: 99%

Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration

Halim

Zhang

et al. 2021

ACS Biomater. Sci. Eng.

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“…The hydrogels, therefore, come as a promising material that fulfills the entire criteria for an ideal drug delivery system. Studies have shown that the chitosan-based hydrogels contribute to inflammatory response modulation, tissue repair, gain in locomotor function recovery, and induces neural tissue repair to treat SCI [123,124]. Chitosan and water as fragmented physical hydrogel suspension (Chitosan-FPHS) promoted reconstitution of spinal tissue and vasculature while diminishing the fibrous glial scarring in post SCI rat models [123].…”

Section: Hydro/nano/in-situ Gelling Systemsmentioning

confidence: 99%

Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

et al. 2021

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Spinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplanted stem cells. Biomaterial scaffolds utilizing chitosan have shown certain therapeutic effects on spinal cord injury repair with some limitations. Chitosan-based delivery in stem cell transplantation is another strategy that has shown decent success. Stem cells can be directed to differentiate into neurons or glia in vitro. Stem cell-based therapy, biopolymer chitosan delivery strategies, and scaffold-based therapeutic strategies have been advancing as a combinatorial approach for spinal cord injury repair. In this review, we summarize the recent progress in the treatment strategies of SCI due to the use of bioactivity of chitosan-based drug delivery systems. An emphasis on the role of chitosan in neural regeneration has also been highlighted.

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“…The biomaterials approach can act within the previously discussed context of delivering drugs to the CNS that serve a protective function [145]. Also, the ECM-like scaffolding biomaterials, such as hydrogel-based scaffolds, can support stem cell transplants within the context of a planned neural regeneration in the spinal cord, thanks to which they contain immunomodulatory and regenerative factors allowing the cells within the spinal cord to communicate with each other successfully [146,147]. In addition to biomaterials, stem cells, growth factors, drugs, and exosomes can regenerate the injured spine [148].…”

Section: Biomaterials For Spinal Cord Injurymentioning

confidence: 99%

Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

Saghazadeh

Rezaei

2021

emergent mater.

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COVID-19 can affect the central nervous system (CNS) indirectly by inflammatory mechanisms and even directly enter the CNS. Thereby, COVID-19 can evoke a range of neurosensory conditions belonging to infectious, inflammatory, demyelinating, and degenerative classes. A broad range of non-specific options, including anti-viral agents and anti-inflammatory protocols, is available with varying therapeutic. Due to the high mortality and morbidity in COVID-19–related brain damage, some changes to these general protocols, however, are necessary for ensuring the delivery of therapeutic(s) to the specific components of the CNS to meet their specific requirements. The biomaterials approach permits crossing the blood–brain barrier (BBB) and drug delivery in a more accurate and sustained manner. Beyond the BBB, drugs can protect neural cells, stimulate endogenous stem cells, and induce plasticity more effectively. Biomaterials for cell delivery exist, providing an efficient tool to improve cell retention, survival, differentiation, and integration. This paper will review the potentials of the biomaterials approach for the damaged CNS in COVID-19. It mainly includes biomaterials for promoting synaptic plasticity and modulation of inflammation in the post-stroke brain, extracellular vesicles, exosomes, and conductive biomaterials to facilitate neural regeneration, and artificial nerve conduits for treatment of neuropathies. Also, biosensing surfaces applicable to the first sensory interface between the host and the virus that encourage the generation of accelerated anti-viral immunity theoretically offer hope in solving COVID-19.

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Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

Abstract: Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal functionality, directly affecting the quality of the patient's life. Due to the central nervous system’s (CNS)...

Cited by 50 publications

References 254 publications

Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration

Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration

Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

Biosensing surfaces and therapeutic biomaterials for the central nervous system in COVID-19

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