Design of monodispersed PVP functionalized biocompatible manganese ferrite nanoparticles for hyperthermia application

Ghutepatil, P. R.; Khot, Vishwajeet M.; Salunkhe, A.B.

doi:10.1016/j.matpr.2022.03.417

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Although PVP is intrinsically hydrophilic, it can be modified to become hydrophobic in order to meet certain application needs. Notably, PVP is well known for its biocompatibility, making it an excellent option for pharmaceutical and biomedical applications [28,29]. Moreover, PVP exhibits exceptional film-forming capabilities [30].…”

Section: Introductionmentioning

confidence: 99%

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Jebali,

Vayer,

Belal

et al. 2024

Materials

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In this work, a water-soluble (hydrophilic) polymer was used to form a hydrophobic coating on silicon substrates (Si) in a two-step process comprising (i) the transformation of the polymer into an insoluble material and (ii) the structuring of this coating at nanometric and micrometric scales to achieve the desired hydrophobic behavior. Polyvinylpyrrolidone (PVP), a water-soluble commodity polymer, was crosslinked using benzophenone and UV irradiation to produce a water-insoluble PVP coating. The nanometric scale roughness of the coating was achieved by the addition of silica nanoparticles (NPs) in the coating. The micrometric scale roughness was achieved by forming vertical pillars of PVP/NP coating. To prepare these pillars, a perforated polystyrene (PS) template was filled with a PVP/NP suspension. Micrometer scale vertical pillars of PVP/silica NPs were produced by this method, which allowed us to tune the wettability of the surface, by combining the micrometric scale roughness of the pillars to the nanometric scale roughness provided by the nanoparticles at the surface. By adjusting the various experimental parameters, a hydrophobic PVP coating was prepared with a water contact angle of 110°, resulting in an improvement of more than 80% compared to the bare flat film with an equal amount of nanoparticles. This study paves the way for the development of a more simplified experimental approach, relying on a blend of polymers containing PVP and NPs, to form the micro/nano-structured PVP pillars directly after the deposition step and the selective etching of the sacrificial major phase.

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Section: Introductionmentioning

confidence: 99%

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Jebali,

Vayer,

Belal

et al. 2024

Materials

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Designing Highly Efficient Temperature Controller for Nanoparticles Hyperthermia

et al. 2022

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This paper presents various control system design techniques for temperature control of Magnetic Fluid hyperthermia. The purpose of this research is to design a cost-effective, efficient, and practically implementable temperature controller for Magnetic Fluid hyperthermia, which is presently under research as a substitute to the radiation and chemotherapy treatment of cancer. The principle of this phenomenon centers on the greater sensitivity of tumor cells to changes in temperature in comparison to healthy cells. Once the nanoparticles reach the desired tissue, it can then be placed in a varying magnetic field to dissipate the heat locally by raising the temperature to 45 °C in order to kill cancerous cells. One of the challenging tasks is to maintain the temperature strictly at desired point i.e., 45 °C. Temperature controller for magnetic fluid hyperthermia provides the tight control of temperature in order to avoid folding of proteins and save the tissues around the cancerous tissue from getting destroyed. In contrast with most of the existing research on this topic, which are based on linear control strategies or their improved versions, the novelty of this research lies in applying nonlinear control technique like Sliding Mode Control (SMC) to accurately control the temperature at desired value. A comparison of the control techniques is presented in this paper, based on reliability, robustness, precision and the ability of the controller to handle the non-linearities that are faced during the treatment of cancer. SMC showed promising results in terms of settling time and rise time. Steady state error was also reduced to zero using this technique.

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Citrate coated iron oxide nanoparticles: Synthesis, characterization, and performance in protein adsorption

Portilla,

López,

Escobedo

et al. 2024

AIMSMATES

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<p>Magnetic nanoparticles (MNPs) are extensively utilized in biomedicine as part of controlled drug release systems, hyperthermia, and magnetic resonance imaging. Surface modification of MNPs not only enhances their stability and biocompatibility but also increases affinity with certain molecules, allowing them to be used in protein separation and adsorption processes. This article reports the synthesis and characterization of iron oxide MNPs functionalized with citric acid (IONPs@CA) to evaluate their performance in protein adsorption. The nanoparticles were characterized using various techniques such as transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FT-IR). The percentage of lysozyme (Lyz) adsorbed by IONPs@CA was 84.9%, while the IONPs sample only adsorbed 5.9%. In silico evaluation results showed some repulsion bonds obtained in Lyz-IONPs and hydrogen bonds, carbon-hydrogen bonds, and van der Waals interactions in Lyz-IONPs@CA. These results may be novel since no previous research was found specifying this type of interaction between lysozyme and IONPs and/or IONPs@CA. The maximum adsorption efficiency obtained for the coated nanoparticles was 88.3%.</p>

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Design of monodispersed PVP functionalized biocompatible manganese ferrite nanoparticles for hyperthermia application

Cited by 3 publications

References 23 publications

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Engineered Nanocomposite Coatings: From Water-Soluble Polymer to Advanced Hydrophobic Performances

Designing Highly Efficient Temperature Controller for Nanoparticles Hyperthermia

Citrate coated iron oxide nanoparticles: Synthesis, characterization, and performance in protein adsorption

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