“…Mainly the relevance of osteointegration in the implant's longevity as well as in the mechanical stimulation of bone is studied [14,28,33].Authors mainly considered a static scenario, i.e. an implant is inserted on the bone and loaded in different forms, or the bone tissue mechanical characteristics were tested, or different implant materials were tried, and the stress, strains or displacements were investigated [7,9,12,25,29,33,37,37].It has been widely observed the importance of implant's design on the osteointegration, implying that "one implant fits all" is not possible anymore [32,37]. So, more studies on the influence of different parameters involved in the mechanics of dental implant are needed, for example, considering implant material as metamaterials [2,6,15,16,26] Our study concentrates on the bone's natural remodelling process and the interaction with the implant in the case where a bone substitute material is used to improve fixation.…”