Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers

Design, Synthesis and Calcium Channel Blocking Activity of Diltiazem- Verapamil Hybrid Molecules

“…The compounds were dissolved with the help of ethanol, as detailed under the experimental section, that was added to the control runs to eliminate any solvent effect on the aortic strips contractions. We have previously applied the same protocol to evaluate the calcium channel blocking activities of a series of diltiazem-like compounds [17]. The same protocol was also applied in the current research for assessing the activity of the newly designed compounds and the two parent drugs but after incubation for 2-hours, before adding the contractile calcium ions.…”

Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor

“…The protonation of piperazine is employed as a simple way of protection of the secondary nitrogen atom resulting in the suppression of a competitive reaction leading to disubstituted derivatives. Although the principle of a protonated piperazine was rarely mentioned in literature [26][27][28]32], it was not applied in a broader scale for the synthesis of other monosubstituted piperazines. Nonetheless, our long-time research has shown that the principle is applicable to the synthesis of a wide range of monosubstituted piperazines.…”

“…In case of some benzyl-and substituted benzyl derivatives, especially fluorinated, above-mentioned issues were suppressed and monosubstituted products were obtained in very high yields [20,[26][27][28][29][30][31][32]. However, the same reaction scheme does not usually work sufficiently well in the case of other substituted benzyl derivatives (yields are usually significantly decreased).…”

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization

“…The amine building blocks 17, 26 and 29 were commercially available. Compounds 11 [44], 12 [45], 13 [46], 14 [47], 15 [48], 16 [49], 18 [49], 19 [50], 20 [51], 21 [52], 22 [53], 23 [53], 27…”