Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction

Prasanthi, G.; Prasad, K. V. S. R. G.; Bharathi, K.

doi:10.1016/j.ejmech.2013.06.006

Cited by 23 publications

(7 citation statements)

References 21 publications

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“…Agelasines are known to possess antimicrobial and cytotoxic properties (Nakamura et al, 1984;Vik et al, 2006). Biological activity of several compounds containing a piperonyl ring has been reported against viruses (Day et al, 2002), amoebae (Wani et al, 2012), cancerous cells (de Olivetra et al, 2010;Mathew et al, 2011), and they possess anti-proliferative and anticonvulsant properties (Prasanthi et al, 2013). Another study demonstrated high antibacterial activities of piperonyl triazoles against Bacillus subtilis, E. coli, Klebsiella pneumoniae, and Micrococcus luteus (Srinivas and Sunitha, 2016).…”

Section: Discussionmentioning

confidence: 99%

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

et al. 2020

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“…Further, the prediction data of the molecular properties supports that compound 80 might involve hydrogen bonding interaction with target site, and displayed good binding in silico absorption and lower binding rate of plasma to protein, which made it to be a good candidate for treatment of epilepsy [64].…”

Section: The Pyridine Functional Groupmentioning

confidence: 96%

Current Research on Antiepileptic Compounds

2015

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Epilepsy affects about 1% of the world's population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy.

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“…The 1,4-dihydropyridine (DHP) nucleus has proved to be a biologically advantaged and versatile platform, displaying various biotic actions, such as anticancer, − anticonvulsant, − antidiabetic, − anti-inflammatory, , and antihypertensive, for the treatment of vasospastic angina, as antibacterial agents and antifungal agents, as well as in the management of tuberculosis …”

Section: Introductionmentioning

confidence: 99%

Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species

et al. 2022

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The pharmacologically privileged DHP derivatives were synthesized using the pragmatic multicomponent Hantzsch synthesis to screen the antidiabetic activity. Initially, the candidates were screened using an in vivo blood glucose test, where compound 8b showed the most prominent antidiabetic effect (% potency = 218%) compared to glimepiride. Then, a propositioned structure–activity relationship study was executed to reveal that longer side chains decreased the DHP’s antidiabetic action. Mechanistically, compound 8b diminished ROS in β-cells and muscle cells simultaneously, which was proved by enhanced serum biochemical markers. Also, compound 8b decreased blood glucose by α-glucosidase inhibition (IC50 = 4.48 ± 0.32 μM), compared to acarbose (7.40 ± 0.41 μM), based selectively on the plasma window of 8b. Acarbose demonstrated auspicious inhibitor activity according to the binding affinity (ΔG binding), which was slightly lower than that of compound 8b (−54.7 and −46.8 kcal/mol, respectively). During the 100 ns molecular dynamics simulations, the structural and energetic assessments exposed the high consistency of compound 8b to bind to the α-glucosidase.

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Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction

Cited by 23 publications

References 21 publications

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes

Current Research on Antiepileptic Compounds

Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species

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