Design, synthesis, and three-dimensional structural characterization of a constrained Ω-loop excised from interleukin-1α

Sarabu, Ramakanth; Lovey, Kathleen; Madison, Vincent; Fry, David C.; Greeley, David N.; Cook, Charles M.; Olson, Gary L.

doi:10.1016/s0040-4020(01)90219-4

Cited by 18 publications

(6 citation statements)

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“…As detailed above, the homology model structures of IgE suggest that its binding domain is contained within a complex turn connecting antiparallel |3-strands. Tliis is properly classified as a Q.-\oop (90). Tlie Pro343-Ser353 motif cotnprises a sector within this loop, shown in Eig.…”

Section: Structure-based Design Of Antiallergic Drugsmentioning

confidence: 99%

Peptide blocking of IgE/receptor interaction: possibilities and pitfalls

Helm

Spivey

Padlan

1997

Allergy

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Section: Structure-based Design Of Antiallergic Drugsmentioning

confidence: 99%

Peptide blocking of IgE/receptor interaction: possibilities and pitfalls

Helm

Spivey

Padlan

1997

Allergy

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“…Alternatively, molecules that replicate the geometry of β-turns -including pyridine analogs, in some cases in coordination of metal cations -are able to reverse the direction of β-strands and bring their backbones into range for hydrogen bonds to stabilize a β-sheet conformation [114,119]. Finally, adoption of omega loops -hydrogen-bonded loops of irregular backbone dihedral angles that participate in molecular recognition, protein folding or stabilization [120] -has been achieved using naphthalene amino acid derivatives [121]. Constraint of non-helical proteins conveys benefits such as protease resistance [122] in a similar way to α-helices.…”

Section: Constrained Secondary Structuresmentioning

confidence: 99%

Library Construction, Selection and Modification Strategies to Generate Therapeutic Peptide-Based Modulators of Protein–Protein Interactions

Baxter

Ullman²,

Mason

2014

Future Med. Chem.

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In the modern age of proteomics, vast numbers of protein-protein interactions (PPIs) are being identified as causative agents in pathogenesis, and are thus attractive therapeutic targets for intervention. Although traditionally regarded unfavorably as druggable agents relative to small molecules, peptides in recent years have gained considerable attention. Their previous dismissal had been largely due to the susceptibility of unmodified peptides to the barriers and pressures exerted by the circulation, immune system, proteases, membranes and other stresses. However, recent advances in high-throughput peptide isolation techniques, as well as a huge variety of direct modification options and approaches to allow targeted delivery, mean that peptides and their mimetics can now be designed to circumvent many of these traditional barriers. As a result, an increasing number of peptide-based drugs are reaching clinical trials and patients beyond.

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“…This initial work also laid the groundwork for much subsequent analysis of the role of omega (and other loops) in protein structure, function, and dynamics (see, for example, see Refs. 46–64). George has recently applied methods similar to those he used to classify and categorize proteins (what we call a “George‐like analysis”) to RNA structure and RNA structure formation 65–67.…”

Section: Illustrationmentioning

confidence: 99%