Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: AnIn-VitroKinetic Study

Abstract

In the present investigation gelatin nanoparticles have been synthesized and characterized by various techniques like FTIR, scanning electron microscopy, particle size analysis and surface charge measurements. The particles were allowed to swell in phosphate buffer saline (PBS) and the influence of various factors like chemical composition of nanoparticles, pH and temperature of the swelling bath was investigated on the water intake capacity of the gelatin nanoparticles. The particles were loaded with insulin and the release kinetics of insulin was studied in PBS medium under different conditions. The effects of percent loading of drug, chemical composition of nanoparticles and pH, temperature of the release medium were examined on the release profiles of the drug and the possible mechanisms of drug transport were investigated. The chemical stability of the loaded drug (insulin) was also assessed especially under highly acidic conditions of artificial gastric juice.

Polymers in oral insulin delivery

“…Goswami et al developed glutaraldehyde cross-linked gelatin nanoparticles, a swelling-controlled release system for insulin that offers minimum release of insulin at gastric pH while optimum release is seen at intestinal pH [32].…”

Formulation and evaluation of cefuroxim loaded submicron particles for ophthalmic delivery

“…Therefore the neutralization of unreacted glutaraldehyde sites was performed as a supplementary step by treating the prepared nanoparticles repeatedly with L-glutamic acid solution (low pH) as reported by Goswami et al (Goswami et al, 2010).…”

Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

“…Strategies to bypass the tightly packed stratum corneum, the rate-limiting step in transdermal drug penetration, will facilitate topical medication delivery deep into the skin. Several methods have been developed to improve transdermal drug delivery, including chemical enhancers [9,10], nanocarriers [11,12], microneedles [13,14], sonophoresis [15,16], and iontophoresis [17,18]. The biocompatibility and biotoxicity of chemical enhancers and nanocarriers are important issues.…”