Designing of ‘intelligent’ liposomes for efficient delivery of drugs

Voinea, Manuela; Simionescu, Maya

doi:10.1111/j.1582-4934.2002.tb00450.x

Cited by 127 publications

(83 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since their discovery, a large number of studies have been carried out to understand their biophysical and biochemical properties, and possible applications. They have been used as: model membrane systems to study the basic nature of cell membranes [6], in biochemistry and molecular biology [6,18], in analytical methods [18], in microfluidic technologies [19], as a template for the production of nanogels [20], in cosmetics and food technology [21,22], in imaging [23], as drug delivery systems in pharmacology [24][25][26], and in TE [27]. In this section, we will revisit the liposome properties, their formulation/functionalization, preparation methods and stability.…”

Section: Liposomesmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

327

217

View full text Add to dashboard Cite

Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

show abstract

Section: Liposomesmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

327

217

View full text Add to dashboard Cite

show abstract

“…Extended circulation time can be accomplished with smallsized liposomes (< 10 nm) composed of neutral, saturated phospholipids and cholesterol. Furthermore, many modern studies use liposomes with a surface modified with polyethylene glycol (PEG) [162][163][164]. Such modification ("PEGylation") reduces opsonisation of liposomes in plasma and decreases its recognition and removal by the MP system in liver and spleen.…”

Section: Liposomesmentioning

confidence: 99%

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Kabanov

Gendelman

2007

Progress in Polymer Science

242

138

View full text Add to dashboard Cite

Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's age. Alzheimer's disease alone currently affects 4.5 million Americans, and more than $100 billion is spent per year on medical and institutional care for affected people. Such numbers will double in the ensuing decades. Currently disease diagnosis for all disorders is made, in large measure, on clinical grounds as laboratory and neuroimaging tests confirm what is seen by more routine examination. Achieving early diagnosis would enable improved disease outcomes. Drugs, vaccines or regenerative proteins present "real" possibilities for positively affecting disease outcomes, but are limited in that their entry into the brain is commonly restricted across the blood-brain barrier. This review highlights how these obstacles can be overcome by polymer science and nanotechnology. Such approaches may improve diagnostic and therapeutic outcomes. New developments in polymer science coupled with cell-based delivery strategies support the notion that diseases that now have limited therapeutic options can show improved outcomes by advances in nanomedicine.

show abstract

“…An increase in the duration of liposome circulation is attained by decreasing their size to a nanometer range and by modifying their surface with PEG. 97 To alter distribution in the organism, the vector, which is able to direct binding to specific tissues or cells, can be incorporated into liposomal surfaces. Conjugation with antibodies makes liposomes more recognizable by ECs.…”

Section: Liposomesmentioning

confidence: 99%

Nanoscale drug delivery systems and the blood–brain barrier

Alyautdin¹,

Khalin²,

Nafeeza³

et al. 2014

IJN

121

View full text Add to dashboard Cite

The protective properties of the blood–brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs) in the brain’s vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neurons have easier access to the central nervous system (CNS). As a consequence, CNS disorders, including degenerative diseases, can occur independently of an individual’s age. Although the BBB is crucial in regulating the biochemical environment that is essential for maintaining neuronal integrity, it limits drug delivery to the CNS. This makes it difficult to deliver beneficial drugs across the BBB while preventing the passage of potential neurotoxins. Available options include transport of drugs across the ECs through traversing occludins and claudins in the tight junctions or by attaching drugs to one of the existing transport systems. Either way, access must specifically allow only the passage of a particular drug. In general, the BBB allows small molecules to enter the CNS; however, most drugs with the potential to treat neurological disorders other than infections have large structures. Several mechanisms, such as modifications of the built-in pumping-out system of drugs and utilization of nanocarriers and liposomes, are among the drug-delivery systems that have been tested; however, each has its limitations and constraints. This review comprehensively discusses the functional morphology of the BBB and the challenges that must be overcome by drug-delivery systems and elaborates on the potential targets, mechanisms, and formulations to improve drug delivery to the CNS.

show abstract

Designing of ‘intelligent’ liposomes for efficient delivery of drugs

Cited by 127 publications

References 62 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Nanoscale drug delivery systems and the blood–brain barrier

Contact Info

Product

Resources

About

Designing of ‘intelligent’ liposomes for efficient delivery of drugs

Cited by 127 publications

References 62 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Nanoscale drug delivery systems and the blood&ndash;brain barrier

Contact Info

Product

Resources

About

Nanoscale drug delivery systems and the blood–brain barrier