Detecting Deep Brain Stimulation Currents with High Resolution Transcranial Acoustoelectric Imaging

Preston, Chet; Alvarez, Alexander; Barragan, Andres; Kasoff, Willard S.; Witte, Russell S.

doi:10.1109/ultsym.2019.8925649

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Because sensitivity was scaled to the peak current density generated by the DBS (acting as a source), we did not expect detection thresholds to change significantly between liquid and gelatin. We have also extensively characterized the AE signal in conductive Agarose gelatin [50][51][52][53], as well as the effect of salt concentration, temperature, and type (monovalent versus divalent) on the AE signal [30]. We, therefore, do not expect the spatial resolution and sensitivity for tAEI to change dramatically between saline, gel, and brain tissue, although the generated current patterns will depend on the complexity of the medium.…”

Section: Discussion Taei Enables High Resolution Mapping Of Dbs Curre...mentioning

confidence: 99%

High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator

et al. 2020

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Objective. New innovations in deep brain stimulation (DBS) enable directional current steering—allowing more precise electrical stimulation of the targeted brain structures for Parkinson’s disease, essential tremor and other neurological disorders. While intra-operative navigation through MRI or CT approaches millimeter accuracy for placing the DBS leads, no existing modality provides feedback of the currents as they spread from the contacts through the brain tissue. In this study, we investigate transcranial acoustoelectric imaging (tAEI) as a new modality to non-invasively image and characterize current produced from a directional DBS lead. tAEI uses ultrasound (US) to modulate tissue resistivity to generate detectable voltage signals proportional to the local currents. Approach. An 8-channel directional DBS lead (Infinity 6172ANS, Abbott Inc) was inserted inside three adult human skulls submerged in 0.9% NaCl. A 2.5 MHz linear array delivered US pulses through the transtemporal window and focused near the contacts on the lead, while a custom amplifier and acquisition system recorded the acoustoelectric (AE) interaction used to generate images. Main results. tAEI detected monopolar current with stimulation pulses as short as 100 µs with an SNR ranging from 10–27 dB when using safe US pressure (mechanical indices <0.78) and injected current of ~2 mA peak amplitude. Adjacent contacts were discernable along the length and within each ring of the lead with a mean radial separation between contacts of 2.10 and 1.34 mm, respectively. Significance. These results demonstrate the feasibility of tAEI for high resolution mapping of directional DBS currents using clinically-relevant stimulation parameters. This new modality may improve the accuracy for placing the DBS leads, guide calibration and programming, and monitor long-term performance of DBS for treatment of Parkinson’s disease.

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Section: Discussion Taei Enables High Resolution Mapping Of Dbs Curre...mentioning

confidence: 99%

High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator

et al. 2020

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“…The results showed that the SNR of the detected AE signals ranged from 7 to 16 dB at an injection current of 11 mA and a focusing pressure of 2.04 MPa. AEI can provide non-invasive, high-resolution feedback of current diffusion from a directional DBS electrode (Preston et al, 2019 ). In addition, Preston constructed monopolar and dipolar models in saline with and without a human skullcap.…”

Section: Research Progressmentioning

confidence: 99%

Biological current source imaging method based on acoustoelectric effect: A systematic review

Zhang

Liu

et al. 2022

Front. Neurosci.

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Neuroimaging can help reveal the spatial and temporal diversity of neural activity, which is of utmost importance for understanding the brain. However, conventional non-invasive neuroimaging methods do not have the advantage of high temporal and spatial resolution, which greatly hinders clinical and basic research. The acoustoelectric (AE) effect is a fundamental physical phenomenon based on the change of dielectric conductivity that has recently received much attention in the field of biomedical imaging. Based on the AE effect, a new imaging method for the biological current source has been proposed, combining the advantages of high temporal resolution of electrical measurements and high spatial resolution of focused ultrasound. This paper first describes the mechanism of the AE effect and the principle of the current source imaging method based on the AE effect. The second part summarizes the research progress of this current source imaging method in brain neurons, guided brain therapy, and heart. Finally, we discuss the problems and future directions of this biological current source imaging method. This review explores the relevant research literature and provides an informative reference for this potential non-invasive neuroimaging method.

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“…For mapping deep dipole during epilepsy, AEBI showed much better resolution and accuracy [21]. Meanwhile, researchers investigated AEBI as a promising method for noninvasively imaging currents generated by DBS leads [22][23]. It has been demonstrated that AEBI can map DBS currents inside human skulls submerged in 0.9% NaCl solution [24][25].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Deep Brain Stimulation Currents

Zhou,

Song,

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Objective. Deep brain stimulation (DBS) is an effective treatment for neurologic disease and its clinical effect is highly dependent on the DBS leads localization and current stimulating state. However, standard human brain imaging modalities could not provide direct feedback on DBS currents spatial distribution and dynamic changes. Acoustoelectric brain imaging (AEBI) is an emerging neuroimaging method that can directly map current density distribution. Here, we investigate in vivo AEBI of different DBS currents to explore the potential of DBS visualization using AEBI. Method. According to the typical DBS stimulus parameters, four types of DBS currents, including time pattern, waveform, frequency, and amplitude are designed to implement AEBI experiments in living rat brains. Based on acoustoelectric (AE) signals, the AEBI images of each type DBS current are explored and the resolution is quantitatively analyzed for performance evaluation. Furtherly, the AE signals are decoded to characterize DBS currents from multiple perspectives, including time-frequency domain, spatial distribution, and amplitude comparation. Results. The results show that in vivo transcranial AEBI can accurately locate the DBS contact position with a millimeter spatial resolution (<2 mm) and millisecond temporal resolution (<10 ms). Besides, the decoded AE signal at DBS contact position is capable of describing the corresponding DBS current characteristics and identifying current pattern changes. Conclusion. This study first validates that AEBI can localize in vivo DBS contact and characterize different DBS currents. Significance. AEBI is expected to develop into a noninvasive DBS real-time monitoring technology with high spatiotemporal resolution.

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Detecting Deep Brain Stimulation Currents with High Resolution Transcranial Acoustoelectric Imaging

Cited by 5 publications

References 6 publications

High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator

High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator

Biological current source imaging method based on acoustoelectric effect: A systematic review

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Deep Brain Stimulation Currents

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