Detecting molecules and cells labeled with magnetic particles using an atomic magnetometer

Yu, Dindi; Ruangchaithaweesuk, Songtham; Yao, Li; Xu, Shoujun

doi:10.1007/s11051-012-1135-7

Cited by 9 publications

(10 citation statements)

References 43 publications

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“…With more optimization, such as decreased probe-beam fluctuations, uniform pump laser power and optimized spatial separation between the two channels, the gradiometric NMR spectrometer could be capable of detecting NMR signals from samples with natural isotopic abundance for dilute nuclei, which are convenient for chemical analysis. The gradiometric technique is not restricted just to the detection of NMR, but also opens up avenues of investigations of samples that generate magnetic field gradients, such as magnetic nanoparticles used in biomolecular labelling and cell separation [41][42][43]. Moreover, recent theoretical work suggests that it is possible to measure molecular chirality and parity non-conservation effects in ZULF NMR [15,16].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Gradiometer for the Detection of Zero- to Ultralow-Field Nuclear Magnetic Resonance

Jiang

Picazo‐Frutos

et al. 2019

Phys. Rev. Applied

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Magnetic sensors are important for detecting nuclear magnetization signals in nuclear magnetic resonance (NMR). As a complementary analysis tool to conventional high-field NMR, zero-and ultralow-field (ZULF) NMR detects nuclear magnetization signals in the sub-microtesla regime. Current ZULF NMR systems are always equipped with high-quality magnetic shieldings to ensure that ambient magnetic field noise does not dwarf the magnetization signal. An alternative approach is to separate the magnetization signal from the noise based on their differing spatial profiles, as can be achieved using a magnetic gradiometer. Here, we present a gradiometric ZULF NMR spectrometer with a magnetic gradient noise of 17 fTrms cm −1 Hz −1/2 in the frequency range of 100-400 Hz, based on a single vapor cell (0.7×0.7×1.0 cm 3 ). With applied white magnetic-field noise, we show that the gradiometric spectrometer achieves 13-fold enhancement in the signalto-noise ratio (SNR) compared to the single-channel configuration. By reducing the influence of common-mode magnetic noise, this work enables the use of compact and low-cost magnetic shields. Gradiometric detection may also prove to be beneficial for eliminating systematic errors in ZULF-NMR experiments searching for exotic spin-dependent interactions and molecular parity violation.

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Section: Discussionmentioning

confidence: 99%

Magnetic Gradiometer for the Detection of Zero- to Ultralow-Field Nuclear Magnetic Resonance

Jiang

Picazo‐Frutos

et al. 2019

Phys. Rev. Applied

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“…After the separation step, there are various techniques to read out signal from magnetic particles; electrochemical detection [10], magnetometer [11], magnetic remanence [12], magnetoresistance [13,14], hall sensors [15], optical methods such as laser diffraction [16], optical light microscope [17], and fluorescent detection [18]. Common approaches to amplifying the signal from magnetic particle-based biosensors are the use of additional magnetic [16] or nonmagnetic particles, such as labels coated with biomolecules to either bind to a target molecule [19] or bind to magnetic beads [18,20].…”

Section: Introductionmentioning

confidence: 99%

Detection of Proteins Using Nano Magnetic Particle Accumulation-Based Signal Amplification

İçöz

Mzava

2016

Applied Sciences

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Abstract:We report a biosensing method based on magnetic particles where coated magnetic particles are used for immunomagnetic separation, and uncoated magnetic particles are used for signal enhancement. To quantify the signal amplification, optical micrographs are analyzed to measure changes in pixel area and pixel intensity. Microcontact-printed surface receptors are arranged in alternating lines on gold chips, enabling differential calculations. In a model experiment, target molecules-streptavidin-are first captured and separated by biotin-coated magnetic particles, and then exposed to a gold surface functionalized with biotin-coupled bovine serum albumin, forming a sandwich assay. Applying a magnetic field and introducing uncoated magnetic particles resulted in accumulation around magnetic particles in the sandwich assay and enhancement of the contrast to noise ratio at least by eight-fold in a range of 0.1-100 µM.

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“…A recently developed technique based on AM solved the issue of lacking a spectroscopic parameter in magnetic sensing. This technique, termed as force-induced remnant magnetization spectroscopy (FIRMS), implements the binding force of the noncovalent bonds between the ligand on the MNPs and the targeted receptor molecules as a molecular signature for distinguishing different molecular interactions [165,166]. The principle is shown in Figure 11.…”

Section: Atomic Magnetometers (Am)mentioning

confidence: 99%

Detection of magnetic nanomaterials in molecular imaging and diagnosis applications

Yao

2014

Nanotechnology Reviews

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Advances in bionanotechnology promise to allow medical diagnosis and therapy through the channel of molecular imaging. Combining biological science and modern detection techniques, molecular imaging has the ability to penetrate biomedical processes at the molecular and cellular level. Magnetic nanoparticles (MNP), broadly defined as particles of tens of nm to approximately 2 μm in diameter in this review, are playing an increasingly important role in molecular imaging. They act as contrast agents to remarkably enhance the signal. The precise determination of the position and quantity of MNP is critical for these applications. This review describes the advances in the development of detection techniques for magnetic particles used in molecular imaging and diagnosis. The techniques are categorized as high magnetic field techniques and low magnetic field techniques. The high-field studies focus on magnetic resonance imaging (MRI). The ultralow-field (ULF) studies include several of the most recent techniques: giant magnetoresistance sensors, superconducting quantum interference devices, atomic magnetometers, and magnetic particle imaging. The advantages and disadvantages of each method are discussed.

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Detecting molecules and cells labeled with magnetic particles using an atomic magnetometer

Cited by 9 publications

References 43 publications

Magnetic Gradiometer for the Detection of Zero- to Ultralow-Field Nuclear Magnetic Resonance

Magnetic Gradiometer for the Detection of Zero- to Ultralow-Field Nuclear Magnetic Resonance

Detection of Proteins Using Nano Magnetic Particle Accumulation-Based Signal Amplification

Detection of magnetic nanomaterials in molecular imaging and diagnosis applications

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