2012
DOI: 10.4269/ajtmh.2012.12-0182
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Detection of Anti-Yellow Fever Virus Immunoglobulin M Antibodies at 3–4 Years Following Yellow Fever Vaccination

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Cited by 43 publications
(34 citation statements)
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“…Anti-YFV IgG levels rise a few days after those of IgM, and this is detected in almost all patients by day 14 after symptom onset. However, the timing of antibody detection in natural YFV infections has not been well documented using current IIF or ELISA techniques, and the best data have been generated from the study of responses to the live-attenuated YFV vaccine (51)(52)(53). Additionally, the clinical sensitivity of IgM detection for the diagnosis of natural YFV infection remains unclear, but there is evidence from vaccination trials that anti-YFV IgM levels may be lower among patients with previous flavivirus infections (50,54).…”
Section: Anti-yfv Antibody Detectionmentioning
confidence: 99%
“…Anti-YFV IgG levels rise a few days after those of IgM, and this is detected in almost all patients by day 14 after symptom onset. However, the timing of antibody detection in natural YFV infections has not been well documented using current IIF or ELISA techniques, and the best data have been generated from the study of responses to the live-attenuated YFV vaccine (51)(52)(53). Additionally, the clinical sensitivity of IgM detection for the diagnosis of natural YFV infection remains unclear, but there is evidence from vaccination trials that anti-YFV IgM levels may be lower among patients with previous flavivirus infections (50,54).…”
Section: Anti-yfv Antibody Detectionmentioning
confidence: 99%
“…Persistence of IgM after a flavivirus infection has been observed. Anti-WNV IgM could still be detected even after 8 year (7), and immune response to YFV vaccine arouse long term IgM presence (6). Recently, anti-ZIKV IgM and neutralizing antibodies were detected in sera up to 19 months after infection (13).…”
Section: Discussionmentioning
confidence: 99%
“…Flaviviruses (6,7), no study has investigated the levels of anti-ZIKV IgM for more than two years, nor there is a study conducted on long term IgM detection in children with microcephaly.…”
Section: Although Cases Of Persistence Of Igm In Serum Have Been Demomentioning
confidence: 99%
“…74 Despite subsequent waning, measurable IgM antibodies are still present 3-4 years after vaccination in some individuals. 74,75 In comparison, YF-17D-specific IgG antibodies first appear between days 10 and 17 post-vaccination. Importantly, mice can survive experimental YFV infection after passive immunization with humanized IgG.…”
Section: Humoral Immune Responsesmentioning
confidence: 99%