Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus

Abstract

This is the first demonstration of antibodies directed against all p63 and some p73 isoforms in sera from patients diagnosed with OLP.

The diagnostic challenges of separating chronic ulcerative stomatitis from oral lichen planus

“…25,26 The antigen was originally believed to be specific for CUS, but a report by Ebrahimi et al has shown that it can also be found in OLP. 27 The tremendous overlap between CUS and erosive OLP likely is the reason why many CUS cases may have gone undiagnosed and helps explain the low number of CUS cases reported in the literature. 3 The theory that CUS is a subset of OLP makes some sense, given the histopathologic similarities, but there has been no strong evidence to support this hypothesis in the literature.…”

Genes Involved in Epithelial Differentiation and Development are Differentially Expressed in Oral and Genital Lichen Planus Epithelium Compared to Normal Epithelium

“…Still, there is no consensus as to whether or not it is a systemic disease. Neither is the cause of this disease known, even if autoimmunity has been discussed, potentially caused by disturbances in differentiation of the keratinocytes (3,17). In order to gain more insight into these issues, we performed whole genome expression analysis concentrating on the epithelium only.…”

Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus

“…This tissue pattern has been associated with the presence of circulating antibodies that stain the nuclei of epithelial cells on monkey esophagus by indirect IF and that recognize a 70‐kDa antigen, a member of the tumor suppressor gene p53 family . The oncogenic role of this humoral response against p53 protein isoforms – the genes of which are mutated in more than 50% of human cancers – with regard to the development of oral cancer in patients with oral LP has not yet been investigated.…”

“…Autoantibodies against type XVII collagen have been occasionally reported in mucosal LP, especially in patients with vulvar involvement . Autoantibodies with different specificities have also been described, namely against BP230 and different isoforms of the tumor suppressor gene p53 family proteins, including the chronic ulcerative stomatitis antigen of 70‐kDa.…”