Detection of C-Reactive Protein using network-deployable DNA aptamer based optical nanosensor

Ghosh, Shreya; Metlushko, Anna; Chaudhry, Shreya; Dutta, Mitra; Stroscio, Michael A.

doi:10.1109/bhi.2019.8834479

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…The sensor operation has also been tested in human serum spiked with CRP achieving a proper detection in concentrations of 1 mg/L, 3 mg/L and 10 mg/L. Au NPs are also used in [148], although in this case the sensor is based on photoluminescence. It consists in an optical "turn off" nanosensor (also known as molecular beacon), made of a DNA aptamer with a quantum dot (QD) attached on the 5′ terminal and a gold nanoparticle attached on the 3′ terminal and based on fluorescence resonance energy transfer (FRET).…”

Section: Crp (C-reactive Protein)mentioning

confidence: 99%

“…The rise in the CRP concentration decreases the photoluminescence intensity resulting in an increase in quenching efficiency. This device achieves a LOD of 45 ng/L, with a linear range of 75 ng/L-1.65 mg/L in 100 times diluted PBS, and it was also tested with CRP spiked human serum, achieving a detection in the Au NPs are also used in [148], although in this case the sensor is based on photoluminescence. It consists in an optical "turn off" nanosensor (also known as molecular beacon), made of a DNA aptamer with a quantum dot (QD) attached on the 5 terminal and a gold nanoparticle attached on the 3 terminal and based on fluorescence resonance energy transfer (FRET).…”

Section: Crp (C-reactive Protein)mentioning

confidence: 99%

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Optical Biosensors for the Detection of Rheumatoid Arthritis (RA) Biomarkers: A Comprehensive Review

Imas

Zamarreño

Zubiate

et al. 2020

Sensors

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A comprehensive review of optical biosensors for the detection of biomarkers associated with rheumatoid arthritis (RA) is presented here, including microRNAs (miRNAs), C-reactive protein (CRP), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), interleukin-6 (IL-6) and histidine, which are biomarkers that enable RA detection and/or monitoring. An overview of the different optical biosensors (based on fluorescence, plasmon resonances, interferometry, surface-enhanced Raman spectroscopy (SERS) among other optical techniques) used to detect these biomarkers is given, describing their performance and main characteristics (limit of detection (LOD) and dynamic range), as well as the connection between the respective biomarker and rheumatoid arthritis. It has been observed that the relationship between the corresponding biomarker and rheumatoid arthritis tends to be obviated most of the time when explaining the mechanism of the optical biosensor, which forces the researcher to look for further information about the biomarker. This review work attempts to establish a clear association between optical sensors and rheumatoid arthritis biomarkers as well as to be an easy-to-use tool for the researchers working in this field.

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Section: Crp (C-reactive Protein)mentioning

confidence: 99%

Section: Crp (C-reactive Protein)mentioning

confidence: 99%