“…Given studies indicating a similar or worse prognosis in patients with silent compared with painful myocardial ischemia or infarcts (6,7,9,10,14,17,20), particularly among high-risk individuals (15,18,21,36,39,40), continued research on the origin and detection of SI are clearly needed to improve patient care and education. In the meantime, it is suggested that patients reporting perspiration and/or muscle tension (in women) on physical effort be followed up for testing, particularly if other symptoms commonly associated with CAD or ischemic processes, such as dyspnea and fatigue, are also present.…”