Detection of hair root miR-19a as a novel diagnostic marker for psoriasis

Hirao, Hiroki; Jinnin, Masatoshi; Ichihara, Asako; Fujisawa, Akihiko; Makino, Katsunari; Kajihara, Ikko; Sakai, Keisuke; Fukushima, Satoshi; Inoue, Yoshio; Ihn, Hironobu

doi:10.1684/ejd.2013.2190

Cited by 20 publications

(20 citation statements)

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“…Complementary to the results from Lovendorf et al., another study showed that miR‐223 controlled the migration of inflammatory cells to tissue via regulating inflammatory molecules . Hirao et al . showed that relative miR‐19a levels were inversely and significantly correlated with the duration between symptom onset and the first visit to the hospital in patients with psoriasis.…”

Section: Mirna As Potential Biomarkers In Psoriasismentioning

confidence: 72%

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Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

Liu

Han

et al. 2017

Experimental Dermatology

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MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.

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Section: Mirna As Potential Biomarkers In Psoriasismentioning

confidence: 72%

“…Hence, it is suggested that miR‐223 and miR‐143 may serve as a novel biomarker for disease activity of psoriasis . Moreover, miR‐19a, a regulatory miRNA of TNF‐α, were found significantly upregulated only in psoriasis and showed significant difference in ROC analysis . Rie Oyama et al.…”

Section: Mirna As Potential Biomarkers In Psoriasismentioning

confidence: 99%

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

Liu

Han

et al. 2017

Experimental Dermatology

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“…Although miR-19a and miR-19b were found to be the most significant miRNAs of the miR-17-92 cluster, and were reported to have a broad and significant roles in normal or abnormal cells of human body, 18, 19, 20, 21 the exact function and the potential mechanisms of them in gastric cancer has not been fully clarified. We have previously found that the expression of the miR-17-92 cluster members were gradually changed during the differentiation of gastric cancer stem cells, among the six members, miR-19b/20a/92a can regulate the self-renewal of gastric cancer stem cells through activating the Wnt- β -catenin signalling.…”

Section: Discussionmentioning

confidence: 99%

MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

Yang

et al. 2014

Cell Death Dis

105

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The microRNAs 19a and 19b, hereafter collectively referred to as miR-19a/b, were recognised to be the most important miRNAs in the oncomiRs—miR-17-92 cluster. However, the exact roles of miR-19a/b in cancers have not been elucidated. In the present study, miR-19a/b was found to be over-expressed in gastric cancer tissues and significantly associated with the patients' metastasis of gastric cancer. Using gain or loss-of-function in in vitro and in vivo experiments, a pro-metastatic function of miR-19a/b was observed in gastric cancer. Furthermore, reporter gene assay and western blot showed that MXD1 is a direct target of miR-19a/b. Functional assays showed that not only MXD1 had an opposite effect to miR-19a/b in the regulation of gastric cancer cells, but also overexpression of MXD1 reduced both miR-19a/b and c-Myc levels, indicating a potential positive feedback loop among miR-19a/b, MXD1 and c-Myc. In conclusion, miR-17-92 cluster members miR-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc -- MXD1, implicating a novel mechanism for the malignant phenotypes of gastric cancer.

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“…The sequence of hsa‐miR‐214 primer was designed based on miRBase (http://www.mirbase.org). DNA amplification was performed by 50 cycles of denaturation for 5 s at 95 °C and annealing for 20 s at 60 °C …”

Section: Methodsmentioning

confidence: 99%

“…DNA amplification was performed by 50 cycles of denaturation for 5 s at 95°C and annealing for 20 s at 60°C. 17,18 Statistical analysis Differences between two groups were compared using Mann-Whitney's U-test. The analysis of frequency was performed by Fisher's exact probability test.…”

Section: Collection Of Patients' Materialsmentioning

confidence: 99%

microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma

et al. 2015

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Detection of hair root miR-19a as a novel diagnostic marker for psoriasis

Cited by 20 publications

References 0 publications

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma

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